ZNF2 - zinc finger protein 2 Gene

Also Known as A1-5; ZNF661; Zfp661

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 7549

About ZNF2

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,165,809-95,184,317 (from NCBI)

This gene has 5 transcripts (splice variants), 95 orthologues and 174 paralogues. Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

ZNF2 Products (5)

mRNA Protein Name
NM_001017396.3 NP_001017396.1 zinc finger protein 2 isoform b
NM_001282398.2 NP_001269327.1 zinc finger protein 2 isoform c
NM_001291604.2 NP_001278533.1 zinc finger protein 2 isoform d
NM_001291605.2 NP_001278534.1 zinc finger protein 2 isoform e
NM_021088.4 NP_066574.2 zinc finger protein 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF2 Protein Structure

KRAB

KRAB: KRAB box (14 - 54)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (188 - 213)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (216 - 239)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (244 - 267)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (272 - 296)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (301 - 324)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (356 - 380)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (385 - 409)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

zinc finger protein 2

  • zinc finger protein 2.2

ZNF2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ZNF2 Q9BSG1 TRIM41 Homo sapiens Q8WV44
Y2H Array
32296183
Intra
ZNF2 Q9BSG1 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
32296183
Intra
ZNF2 Q9BSG1 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
ZNF2 Q9BSG1 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Holoprosencephaly 5

  • HPE5

  • Holoprosencephaly-5

  • Holoprosencephaly, Type 5
Hemophagocytic Lymphohistiocytosis, Familial, 3

  • Familial Hemophagocytic Lymphohistiocytosis 3

  • FHL3

  • Hplh3

  • Hlh3

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Fungal Meningitis

  • Meningitis, Fungal

  • Mycotic Meningitis
Cryptococcal Meningitis

  • Meningitis, Cryptococcal

  • Meningitis Cryptococcal
Cryptococcosis

  • Cryptococcus Neoformans Infection

  • Torulosis

  • Busse-Buschke'S Disease

  • Cryptococcal Infection

  • European Cryptococcosis

  • Torula

  • Infection By Cryptococcus Neoformans

  • Cryptococcosis Infection

  • European Blastomycosis

  • European Blastomycotic Infection

  • European Blastomycoses Infection

  • Torula Histolytica Infection
Hemophagocytic Lymphohistiocytosis, Familial, 1

  • Familial Hemophagocytic Lymphohistiocytosis

  • Fhl

  • Familial Erythrophagocytic Lymphohistiocytosis

  • Hemophagocytic Syndrome

  • FHL1

  • Hplh1

  • Hlh1

  • Fel

  • Familial Hemophagocytic Lymphohistiocytosis 1

  • Primary Hemophagocytic Lymphohistiocytosis

  • Familial Hlh

  • Hlh

  • Familial Hemophagocytic Lymphocytosis

  • Hemophagocytic Lymphohistiocytosis, Familial

  • Reticulosis, Familial Histiocytic

  • Hemophagocytic Reticulosis, Familial

  • Erythrophagocytic Lymphohistiocytosis, Familial

  • Familial Histiocytic Reticulosis

  • Familial Hemophagocytic Histiocytosis

  • Familial Hemophagocytic Reticulosis

  • Fhlh

  • Hplh

  • Primary Hemophagocytic Hymphohistiocytosis

  • Genetic Hemophagocytic Lymphohistiocytosis

  • Hemophagocytic Lymphohistiocytosis

  • Familial Hemophagocytic Lymphohistiocytosis Type 1
Potocki-Lupski Syndrome

  • PTLS

  • Chromosome 17p11.2 Duplication Syndrome

  • 17p11.2 Microduplication Syndrome

  • Duplication 17p11.2 Syndrome

  • Trisomy 17p11.2

  • Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))

  • 17p11.2 Duplication Syndrome

  • Dup(17)(P11.2p11.2)

  • Pls

  • Chromosome 17, Trisomy 17p11 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS16108 ZNF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus ZNF2 RGD RGD:6500748
Macaca mulatta ZNF2 VGNC VGNC:106247
Bos taurus ZNF2 VGNC VGNC:37221
Mus musculus ZNF2 MGD MGI:1919430
Others ZNF2 NCBI