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REEP5 - receptor accessory protein 5 Gene

Also Known as DP1; TB2; YOP1; POB16; Yip2e; D5S346; C5orf18

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 7905

About REEP5

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:112,876,385-112,922,227 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 89.7), brain (RPKM 63.5) and 25 other tissues.

Summary

Predicted to be involved in endoplasmic reticulum organization and regulation of intracellular transport. Located in endoplasmic reticulum tubular network. [provided by Alliance of Genome Resources, Apr 2022]

REEP5 Products (1)

mRNA	Protein	Name
NM_005669.5	NP_005660.4	receptor expression-enhancing protein 5

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	16762630	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in endoplasmic reticulum tubular network	IDA IDA: Inferred from direct assay	23969831	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REEP5 Protein Structure

TB2_DP1_HVA22

0
100
189 a.a.

Protein Preferred Names	Protein Names
receptor expression-enhancing protein 5	deleted in polyposis 1

REEP5 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	REEP5	Q00765	PITPNC1	Homo sapiens	Q9UKF7-2	Validated Y2H	32296183
Intra	REEP5	Q00765	SNX1	Homo sapiens	Q13596	Validated Y2H	32296183
Intra	REEP5	Q00765	RABAC1	Homo sapiens	Q9UI14	Anti Tag CoIP	35271311
Intra	REEP5	Q00765	RABAC1	Homo sapiens	Q9UI14	Anti Tag CoIP	33961781
Intra	REEP5	Q00765	RABAC1	Homo sapiens	Q9UI14	Anti Tag CoIP	28514442
Intra	REEP5	Q00765	ABHD4	Homo sapiens	Q8TB40	Validated Y2H	32296183
Intra	REEP5	Q00765	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Transitional Papilloma	Transitional Cell Papilloma Transitional Cell Papilloma, Benign
Diamond-Blackfan Anemia 5	DBA5 Rpl35a-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 5
Colorectal Cancer, Hereditary Nonpolyposis, Type 5	HNPCC5 Hereditary Nonpolyposis Colorectal Cancer Type 5 Hereditary Non-Polyposis Colorectal Cancer 5 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 5
Muir-Torre Syndrome	MRTES Keratoacanthoma Muir-Torré Syndrome Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas Multiple Keratoacanthoma, Muir-Torre Type Mts Torre-Muir Syndrome
Retinitis Pigmentosa 77	RP77 Retinitis Pigmentosa, Type 77
Mismatch Repair Cancer Syndrome	Turcot Syndrome Brain Tumor-Polyposis Syndrome 1 Btp1 Syndrome Btps1 Childhood Cancer Syndrome Cmmr-D Syndrome Cmmrds Constitutional Mismatch Repair Deficiency Syndrome Mmr Deficiency Cancer Syndrome, Mismatch Repair Malignant Childhood Neoplasm
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Rectal Benign Neoplasm	Neoplasm Of Rectum Rectal Tumor Rectum Neoplasm Neoplasm Of The Rectum Rectal Neoplasms Primary Rectal Cancer Rectal Ampulla Cancer Cancer Of The Rectum Carcinoma Of Rectum Primary Malignant Neoplasm Of Rectum Rectal Cancer Rectal Carcinoma
Spastic Paraplegia 10, Autosomal Dominant	SPG10 Hereditary Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Type 10 Spastic Paraplegia 10 Spastic Paraplegia 10 With Or Without Peripheral Neuropathy Autosomal Dominant Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Spastic Paraplegia, Autosomal Dominant Paraplegia, Spastic, Autosomal Dominant, Type 10
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS11816	REEP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	REEP5	VGNC	VGNC:76864
Mus musculus	REEP5	MGD	MGI:1270152
Felis catus	REEP5	VGNC	VGNC:64563
Bos taurus	REEP5	VGNC	VGNC:33855
Rattus norvegicus	REEP5	RGD	RGD:1306047
Canis familiaris	REEP5	VGNC	VGNC:45464
Others	REEP5	NCBI