PLEKHF1 - pleckstrin homology and FYVE domain containing 1 Gene

Also Known as APPD; LAPF; PHAFIN1; ZFYVE15

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 79156

About PLEKHF1

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,665,461-29,675,477 (from NCBI)

This gene has 4 transcripts (splice variants), 234 orthologues and 13 paralogues. Ubiquitous expression in fat (RPKM 4.0), spleen (RPKM 2.2) and 24 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in endosome organization; positive regulation of autophagy; and protein localization to plasma membrane. Located in lysosome. Colocalizes with endosome. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHF1 Products (1)

mRNA Protein Name
NM_024310.5 NP_077286.3 pleckstrin homology domain-containing family F member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
22115783 GOA
enables phosphatidylinositol-4-phosphate binding IDA
IDA: Inferred from direct assay
22115783 GOA
enables phosphatidylinositol-5-phosphate binding IDA
IDA: Inferred from direct assay
22115783 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
22115783 GOA
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
22115783 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
22115783 GOA
involved in vesicle organization IMP
IMP: Inferred from mutant phenotype
22115783 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
colocalizes with endosome IDA
IDA: Inferred from direct assay
22115783 GOA
located in lysosome IDA
IDA: Inferred from direct assay
22115783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHF1 Protein Structure

PH

PH: PH domain (39 - 130)

FYVE

FYVE: FYVE zinc finger (148 - 211)

  • 0
  • 100
  • 200
  • 279 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family F member 1

  • PH and FYVE domain-containing protein 1

PLEKHF1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PLEKHF1 Q96S99 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra
PLEKHF1 Q96S99 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra
PLEKHF1 Q96S99 NPM2 Homo sapiens Q86SE8-2
Y2H Array
32296183
Intra
PLEKHF1 Q96S99 NPM2 Homo sapiens Q86SE8-2
Y2H Prey Pooling
32296183
Intra
PLEKHF1 Q96S99 L3MBTL3 Homo sapiens Q96JM7
Y2H Prey Pooling
25416956
Intra
PLEKHF1 Q96S99 L3MBTL3 Homo sapiens Q96JM7
Validated Y2H
25416956
Intra
PLEKHF1 Q96S99 L3MBTL3 Homo sapiens Q96JM7
Y2H Array
25416956
Intra
PLEKHF1 Q96S99 CHIC2 Homo sapiens Q9UKJ5
Validated Y2H
32296183
Intra
PLEKHF1 Q96S99 CAVIN2 Homo sapiens O95810
Y2H Array
32296183
Intra
PLEKHF1 Q96S99 CAVIN2 Homo sapiens O95810
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS10687 PLEKHF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus PLEKHF1 MGD MGI:1919537
Macaca mulatta PLEKHF1 VGNC VGNC:76085
Felis catus PLEKHF1 VGNC VGNC:64224
Bos taurus PLEKHF1 VGNC VGNC:33012
Canis familiaris PLEKHF1 VGNC VGNC:44675
Rattus norvegicus PLEKHF1 RGD RGD:1310544
Others PLEKHF1 NCBI