CENPO - centromere protein O Gene
Also Known as CENP-O; MCM21R; ICEN-36
生物種: Homo sapiens
About CENPO
This gene has 9 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in placenta (RPKM 11.4), testis (RPKM 8.5) and 24 other tissues.
Summary
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during Mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
CENPO Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001199803.3 | NP_001186732.1 | centromere protein O isoform 2 |
| NM_001322101.2 | NP_001309030.1 | centromere protein O isoform 1 |
| NM_024322.4 | NP_077298.1 | centromere protein O isoform 1 |
CENPO Protein Structure
CENP-O: Cenp-O kinetochore centromere component (121 - 197)
- 0
- 100
- 200
- 300 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
centromere protein O |
|
CENPO Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
CENPO | Q9BU64 | NECAB2 | Homo sapiens | Q7Z6G3-2 | 25416956 | |
|
Intra
|
CENPO | Q9BU64 | NECAB2 | Homo sapiens | Q7Z6G3-2 | 25416956 | |
|
Intra
|
CENPO | Q9BU64 | FOS | Homo sapiens | Q6FG41 | 25416956 | |
|
Intra
|
CENPO | Q9BU64 | CENPP | Homo sapiens | Q6IPU0 | 25416956 | |
|
Intra
|
CENPO | Q9BU64 | CENPP | Homo sapiens | Q6IPU0 | 32296183 | |
|
Intra
|
CENPO | Q9BU64 | CENPP | Homo sapiens | Q6IPU0 | 25416956 | |
|
Intra
|
CENPO | Q9BU64 | CENPP | Homo sapiens | Q6IPU0 | 25416956 | |
|
Intra
|
CENPO | Q9BU64 | CENPP | Homo sapiens | Q6IPU0 | 32296183 | |
|
Intra
|
CENPO | Q9BU64 | CENPP | Homo sapiens | Q6IPU0 | 26496610 | |
|
Intra
|
CENPO | Q9BU64 | CENPP | Homo sapiens | Q6IPU0 | 33961781 | |
|
Intra
|
CENPO | Q9BU64 | DCDC2 | Homo sapiens | Q9UHG0 | 32296183 | |
|
Intra
|
CENPO | Q9BU64 | DCDC2 | Homo sapiens | Q9UHG0 | 32296183 | |
|
Intra
|
CENPO | Q9BU64 | DCDC2 | Homo sapiens | Q9UHG0 | 32296183 | |
|
Intra
|
CENPO | Q9BU64 | FOSB | Homo sapiens | P53539 | 32296183 | |
|
Intra
|
CENPO | Q9BU64 | FOSB | Homo sapiens | P53539 | 32296183 | |
|
Intra
|
CENPO | Q9BU64 | CEP170P1 | Homo sapiens | Q96L14 | 25416956 | |
|
Intra
|
CENPO | Q9BU64 | CEP170P1 | Homo sapiens | Q96L14 | 25416956 | |
|
Intra
|
CENPO | Q9BU64 | CEP170P1 | Homo sapiens | Q96L14 | 16189514 | |
|
Intra
|
CENPO | Q9BU64 | CEP170P1 | Homo sapiens | Q96L14 | 19447967 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Body Mass Index Quantitative Trait Locus 19 |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| 3-Methylglutaconic Aciduria With Cataracts, Neurologic Involvement And Neutropenia |
|
|
| 3-Methylglutaconic Aciduria, Type Iv |
|
|
| Type 1 Diabetes Mellitus 2 |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Rattus norvegicus | CENPO | RGD | RGD:1590328 |
| Felis catus | CENPO | VGNC | VGNC:60759 |
| Mus musculus | CENPO | MGD | MGI:1923800 |
| Canis familiaris | CENPO | VGNC | VGNC:39110 |
| Bos taurus | CENPO | VGNC | VGNC:27183 |
| Macaca mulatta | CENPO | VGNC | VGNC:71118 |
| Others | CENPO | NCBI |