GEMIN7 - gem nuclear organelle associated protein 7 Gene

Also Known as SIP3

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 79760

About GEMIN7

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,075,627-45,091,518 (from NCBI)

This gene has 5 transcripts (splice variants) and 178 orthologues. Ubiquitous expression in lymph node (RPKM 4.5), spleen (RPKM 4.2) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GEMIN7 Products (5)

mRNA	Protein	Name
NM_001007269.2	NP_001007270.1	gem-associated protein 7
NM_001007270.2	NP_001007271.1	gem-associated protein 7
NM_001319054.1	NP_001305983.1	gem-associated protein 7
NM_001319055.2	NP_001305984.1	gem-associated protein 7
NM_024707.3	NP_078983.1	gem-associated protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	12065586	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in spliceosomal snRNP assembly	EXP EXP: Inferred from Experiment	12067652	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Gemini of coiled bodies	IDA IDA: Inferred from direct assay	20513430	GOA
part of SMN complex	IDA IDA: Inferred from direct assay	17178713	GOA
part of SMN complex	IPI IPI: Inferred from physical interaction	17178713	GOA
part of SMN-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12065586	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
located in nuclear body	IDA IDA: Inferred from direct assay	12065586	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12065586	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GEMIN7 Protein Structure

Gemin7

0
100
131 a.a.

Protein Preferred Names	Protein Names
gem-associated protein 7	gemin-7

GEMIN7 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	GEMIN7	Q9H840	STRAP	Homo sapiens	Q9Y3F4	Anti Tag CoIP	33961781
Intra	GEMIN7	Q9H840	STRAP	Homo sapiens	Q9Y3F4	Pull Down	15848170
Intra	GEMIN7	Q9H840	STRAP	Homo sapiens	Q9Y3F4	Anti Tag CoIP	26496610
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Y2H Array	31515488
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Y2H Prey Pooling	25416956
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Validated Y2H	25416956
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Y2H Prey Pooling	32296183
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	26496610
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Y2H Array	25416956
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	33961781
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Y2H Array	32296183
Intra	GEMIN7	Q9H840	GEMIN6	Homo sapiens	Q8WXD5	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Cerebellar Ataxia Type 9	Sca9
Childhood Spinal Muscular Atrophy	Spinal Muscular Atrophies Of Childhood Survival Motor Neuron Spinal Muscular Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS05370	GEMIN7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	GEMIN7	VGNC	VGNC:29320
Canis familiaris	GEMIN7	VGNC	VGNC:41177
Mus musculus	GEMIN7	MGD	MGI:1916981
Rattus norvegicus	GEMIN7	RGD	RGD:1597035
Others	GEMIN7	NCBI