PPFIA3 - PTPRF interacting protein alpha 3 Gene

Also Known as LPNA3

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 8541

About PPFIA3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,119,544-49,151,026 (from NCBI)

This gene has 13 transcripts (splice variants), 283 orthologues and 5 paralogues. Biased expression in brain (RPKM 10.8), skin (RPKM 6.5) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane Protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize Phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]

PPFIA3 Products (1)

mRNA Protein Name
NM_003660.4 NP_003651.1 liprin-alpha-3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
12923177 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
23124857 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPFIA3 Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (838 - 900)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (954 - 1015)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (1040 - 1107)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1194 a.a.
Protein Preferred Names Protein Names

liprin-alpha-3

  • liprin

PPFIA3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PPFIA3 O75145 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
PPFIA3 O75145 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra
PPFIA3 O75145 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
PPFIA3 O75145 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
PPFIA3 O75145 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
PPFIA3 O75145 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
PPFIA3 O75145 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra
PPFIA3 O75145 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra
PPFIA3 O75145 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
PPFIA3 O75145 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
PPFIA3 O75145 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
PPFIA3 O75145 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
PPFIA3 O75145 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Syndromic X-Linked Intellectual Disability Najm Type

  • Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia

  • Micpch

  • X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS10941 PPFIA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta PPFIA3 VGNC VGNC:76236
Canis familiaris PPFIA3 VGNC VGNC:44845
Bos taurus PPFIA3 VGNC VGNC:33191
Rattus norvegicus PPFIA3 RGD RGD:620054
Mus musculus PPFIA3 MGD MGI:1924037
Felis catus PPFIA3 VGNC VGNC:68983
Others PPFIA3 NCBI