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DLGAP1 - DLG associated protein 1 Gene

Also Known as DAP1; GKAP; DAP-1; SAPAP1; DLGAP1A; DLGAP1B; DAP-1-BETA; DAP-1-ALPHA

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9229

About DLGAP1

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:3,496,032-4,455,307 (from NCBI)

This gene has 22 transcripts (splice variants), 286 orthologues and 4 paralogues. Biased expression in brain (RPKM 19.8), testis (RPKM 1.7) and 2 other tissues.

Summary

Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; regulation of postsynaptic neurotransmitter receptor activity; and regulation of proteasomal protein catabolic process. Predicted to be located in plasma membrane. Predicted to be part of postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2022]

DLGAP1 Products (29)

mRNA	Protein	Name
NM_001003809.3	NP_001003809.1	disks large-associated protein 1 isoform 2
NM_001242761.2	NP_001229690.1	disks large-associated protein 1 isoform 3
NM_001242762.2	NP_001229691.1	disks large-associated protein 1 isoform 4
NM_001242763.2	NP_001229692.1	disks large-associated protein 1 isoform 5
NM_001242764.2	NP_001229693.1	disks large-associated protein 1 isoform 6
NM_001242765.2	NP_001229694.1	disks large-associated protein 1 isoform 7
NM_001242766.2	NP_001229695.1	disks large-associated protein 1 isoform 8
NM_001308390.2	NP_001295319.1	disks large-associated protein 1 isoform 9
NM_001398525.1	NP_001385454.1	disks large-associated protein 1 isoform 10
NM_001398526.1	NP_001385455.1	disks large-associated protein 1 isoform 10
NM_001398527.1	NP_001385456.1	disks large-associated protein 1 isoform 1
NM_001398528.1	NP_001385457.1	disks large-associated protein 1 isoform 11
NM_001398530.1	NP_001385459.1	disks large-associated protein 1 isoform 12
NM_001398531.1	NP_001385460.1	disks large-associated protein 1 isoform 13
NM_001398532.1	NP_001385461.1	disks large-associated protein 1 isoform 14
NM_001398533.1	NP_001385462.1	disks large-associated protein 1 isoform 15
NM_001398534.1	NP_001385463.1	disks large-associated protein 1 isoform 16
NM_001398535.1	NP_001385464.1	disks large-associated protein 1 isoform 17
NM_001398536.1	NP_001385465.1	disks large-associated protein 1 isoform 18
NM_001398537.1	NP_001385466.1	disks large-associated protein 1 isoform 19
NM_001398539.1	NP_001385468.1	disks large-associated protein 1 isoform 20
NM_001398540.1	NP_001385469.1	disks large-associated protein 1 isoform 21
NM_001398541.1	NP_001385470.1	disks large-associated protein 1 isoform 22
NM_001398542.1	NP_001385471.1	disks large-associated protein 1 isoform 23
NM_001398543.1	NP_001385472.1	disks large-associated protein 1 isoform 24
NM_001398544.1	NP_001385473.1	disks large-associated protein 1 isoform 25
NM_001398545.1	NP_001385474.1	disks large-associated protein 1 isoform 26
NM_001398546.1	NP_001385475.1	disks large-associated protein 1 isoform 27
NM_004746.4	NP_004737.2	disks large-associated protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLGAP1 Protein Structure

GKAP

0
200
400
600
800
977 a.a.

Protein Preferred Names	Protein Names
disks large-associated protein 1	PSD-95/SAP90 binding protein 1

DLGAP1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DLGAP1	O14490	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	DLGAP1	O14490	DLG4	Homo sapiens	P78352	Y2H Pooling	21653829
Intra	DLGAP1	O14490	DLG4	Homo sapiens	P78352	FPS	22117215

Cross: Cross-species interaction Intra: Intraspecies interaction

DLGAP1 抗体

製品番号	製品名	アプリケーション	反応性
HY-P85363	SAPAP1 Antibody (YA5055)	IHC-P, ICC/IF, ELISA	Human
HY-P85363A	SAPAP1 Antibody (YA5055)(PBS only)	IHC-P, ICC/IF, ELISA	Human

関連疾患

Diseases	Alias
Retinitis Pigmentosa 55	RP55 Retinitis Pigmentosa, Type 55
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Transient Tic Disorder
Childhood Acute Megakaryoblastic Leukemia	Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Phelan-Mcdermid Syndrome	Chromosome 22q13.3 Deletion Syndrome 22q13.3 Deletion Syndrome Telomeric 22q13 Monosomy Syndrome PHMDS Deletion 22q13 Syndrome 22q13.3 Deletion Deletion 22q13.3 Syndrome Monosomy 22q13 Monosomy 22q13.3 22q13 Deletion Syndrome Monosomy 22q13 Syndrome 22q13 Deletion Chromosome Deletion
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Body Dysmorphic Disorder	Dysmorphophobia Body Dysmorphia Dysmorphic Syndrome Body Dysmorphic Disorders
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03801	DLGAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	DLGAP1	MGD	MGI:1346065
Canis familiaris	DLGAP1	VGNC	VGNC:39979
Rattus norvegicus	DLGAP1	RGD	RGD:620223
Bos taurus	DLGAP1	VGNC	VGNC:28088
Felis catus	DLGAP1	VGNC	VGNC:80437
Macaca mulatta	DLGAP1	VGNC	VGNC:97759
Others	DLGAP1	NCBI