HBV-IN-22
HBV-IN-22 (Compound LC5f) is an inhibitor of HBV DNA replication with IC50 values of 0.71 μM and 0.84 μM against wild-type and agent resistant HBV strains, respectively.
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- CAS 番号: 2338573-94-5
- 分子式: C26H29N3O2S2
- 分子量:479.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
IC50: 0.71 µM (wild-type HBV DNA replication), 0.84 µM (drug resistant HBV DNA replication)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 2.2.15 | CC50 |
>10 μM
Compound: LC5f
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Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay
Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay
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[PMID: 35123297] |
| HepG2 2.2.15 | CC50 |
15.79 μM
Compound: 5f
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Cytotoxicity against human HepG2.2.15 cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 31091479] |
| HepG2 2.2.15 | IC50 |
0.83 μM
Compound: LC5f
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Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication
Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication
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[PMID: 35123297] |
化学情報
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CAS 番号 2338573-94-5
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分子量 479.66
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分子式 C26H29N3O2S2
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SMILES
CCN(CCOC1=CC=C2N=C(N(C(C2=C1)=O)CC3=CC=CS3)SCC4=CC=CC=C4)CC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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PCNA Immunodetection Proliferation Assay
PCNA immunodetection measures proliferative activity by detecting proliferating cell nuclear antigen, a nuclear protein associated with DNA polymerase δ function and DNA replication. The assay readout is the proportion of PCNA-positive nuclei among total counted cells, but PCNA labeling is not identical to BrdU labeling because PCNA can mark late G1/early S-associated replication competence and may persist beyond active DNA synthesis depending on fixation and extraction conditions.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HBV-IN-22 関連分類
HY-146394 関連分類
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