IHVR-17028
Based on 1 Customer Validation
IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.61%
- CAS 番号: 1428247-78-2
- 分子式: C23H44N2O5
- 分子量:428.61
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保管条件:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
500 μM
Compound: 24
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Cytotoxicity against human Huh7.5 cells by MTT assay
Cytotoxicity against human Huh7.5 cells by MTT assay
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[PMID: 23453839] |
| Huh-7 | CC50 |
500 μM
Compound: 3
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Cytotoxicity against human Huh7.5 cells by MTT assay
Cytotoxicity against human Huh7.5 cells by MTT assay
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[PMID: 23747225] |
| Huh-7 | EC50 |
0.2 μM
Compound: 3
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Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis
Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis
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[PMID: 23747225] |
| Huh-7 | EC50 |
0.2 μM
Compound: 24
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Antiviral activity against Tacaribe virus infected in human Huh7.5 cells
Antiviral activity against Tacaribe virus infected in human Huh7.5 cells
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[PMID: 23453839] |
In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC50 values of all >500 μM in?MDBK, Huh7.5 or BHK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection[1]
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Dosage:50 mg/kg
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Administration:Treatment 1 day prior to virus challenging
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Result:Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.
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Animal Model:C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV[1]
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Dosage:25 mg/kg
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Administration:Twice daily at 12 h interval; starting 4 h post infection for 10 days
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Result:Inhibited EBOV infection in mice.
化学情報
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CAS 番号 1428247-78-2
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性状 Oil
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分子量 428.61
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分子式 C23H44N2O5
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Color Colorless to light yellow
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SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCN(C(C(C)(C)C)=O)C2CCCCC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
IHVR-17028 関連分類
HY-139663 関連分類
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