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United States

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製品番号: HY-163473

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IITR08367

IITR08367 is a potent effector pump Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) inhibitor for enhancing the antimicrobial activity of Fosfomycin (HY-B1075A) against Acinetobacter baumannii. IITR08367 acts by interfering with Fosfomycin/H⁺ reverse transporter activity. .

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CAS 番号: 20193-94-6
分子式: C₁₆H₁₈S₂
分子量:274.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

IITR08367 構造式

CAS 番号: 20193-94-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

IITR08367 (0-50 μM) concentration-dependently enhances the activity of Fosfomycin against AbaF-expressing strain of Escherichia coli. A concentration of 50 μM can increase the postantibiotic effect of Fosfomycin by 30 min^[1].
IITR08367 (25 μM; 16 min) disrupts the H⁺ gradient across the membrane, ultimately inhibiting the H⁺ gradient-driven efflux pump without causing membrane damage^[1].
IITR08367 (100 μM; 12 h) and Fosfomycin (64 mg/L) in combination can inhibit A. baumannii RPTC-15 growth^[1].
IITR08367 (100 μM) eliminates the Biofilm Forming Ability of A. baumannii with and without the addition of Fosfomycin^[1].
IITR08367 (12.5-200 μM) is not toxic to erythrocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

RBCs
Concentration:

12.5; 25; 50; 100; 200 μM
Incubation Time:

6 h
Result:

Showed less than 40% cytotoxicity till 200 µM

体内実験

IITR08367 (i.p.; 30 mg/kg; every 12 h for 54 h ) co-administered with Fosfomycin to Urinary tract infections mice shows significant improvement in the damage caused by A. baumannii RPTC-15, with tissue ultrastructure similar to that of uninfected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Urinary tract infections mice^[1]
Dosage:

30 mg/kg; every 12 h for 54 h
Administration:

i.p.
Result:

Reduced the load of A. baumannii RPTC-15 in the kidney and bladder by approximately 3log₁₀.

化学情報

CAS 番号 20193-94-6
分子量 274.44
分子式 C₁₆H₁₈S₂
SMILES

CC1=CC=C(CSSCC2=CC=C(C)C=C2)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Saini M, et al. Small Molecule IITR08367 Potentiates Antibacterial Efficacy of Fosfomycin against Acinetobacter baumannii by Efflux Pump Inhibition. ACS Infect Dis. 2024 Apr 1. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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