Isoangustone A
Based on 1 Customer Validation
Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.0%
- CAS 番号: 129280-34-8
- 分子式: C25H26O6
- 分子量:422.47
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Apoptosis, Autophagy[2]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6.4 μM
Compound: 10
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTS assay
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[PMID: 26841168] |
| HepG2 | IC50 |
4.4 μM
Compound: 10
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
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[PMID: 26841168] |
| LoVo | IC50 |
7.05 μM
Compound: 56; IAA
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Antiproliferative activity against human LoVo cells assessed as inhibition of cell growth by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human LoVo cells assessed as inhibition of cell growth by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
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[PMID: 38142509] |
| MCF7 | IC50 |
6.6 μM
Compound: 10
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay
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[PMID: 26841168] |
| SW480 | IC50 |
6.5 μM
Compound: 10
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Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay
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[PMID: 26841168] |
| SW480 | IC50 |
6.97 μM
Compound: 56; IAA
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Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
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[PMID: 38142509] |
| SW-620 | IC50 |
7.33 μM
Compound: 56; IAA
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Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
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[PMID: 38142509] |
Isoangustone A (10 and 20 μM; 48 and 72 h) suppresses proliferation and induces G1 phase cell cycle arrest in SK-MEL-28 cells[1].
Isoangustone A (10 and 20 μM; 48 h) decreases the abundance of G1 phase-related proteins mediated through the Akt/GSK3β and MKK4/MKK7/JNKs signaling pathways[1].
Isoangustone A suppresses PI3-K, MKK4, and MKK7 kinase activities by directly binding in an ATP-competitive manner[1].
Isoangustone A (20 μM; 0.5-4 h) induces autophagy in colorectal cancer cells by activating AMPK signaling[2].
Isoangustone A (1-20 μM; 0-100 min) inhibits mitochondrial respiration[2].
Isoangustone A (15 μM; 6 h) induces SW480 cells apoptosis[2].
Isoangustone A (1-20 μΜ; 3 days) suppresses mesangial fibrosis and inflammation in human renal mesangial cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-MEL-28
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Concentration:10 and 20 μM
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Incubation Time:48 and 72 h
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Result:Inhibited proliferation in a dose- and time-dependent manner.
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Cell Line:SK-MEL-28
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Concentration:10 and 20 μM
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Incubation Time:48 h
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Result:Caused cell cycle arrest at G1 phase.
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Cell Line:SK-MEL-28
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Concentration:10 and 20 μM
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Incubation Time:48 h
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Result:Inhibited the expression of cyclin D1 and cyclin E. Suppressed phosphorylation of Rb in a dose-dependent manner. Inhibited the phosphorylation of Akt (Ser473, Thr308) and GSK3β (Ser9). Suppressed the phosphorylation of JNK1/2, but had no effect on ERK1/2 or p38.
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Cell Line:SW480 cells
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Concentration:20 μM
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Incubation Time:0.5, 2 and 4 h
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Result:Deformed mitochondria, nondegradable cellular debris were all observable together with autophagic vacuoles in cells after 4 h.
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Cell Line:SW480 cells
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Concentration:15 μM
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Incubation Time:6 h
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Result:Induced elevation of apoptotic Annexin V+/PI- and Annexin V+/PI+ cell populations.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Balb/c nu/nu mice, SK-MEL-28 xenograft model[1]
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Dosage:2 or 10 mg/kg
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Administration:Intraperitoneal injection, daily for 35 days
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Result:Significantly suppressed tumor weight compared to the control group. Markedly inhibited the expression of proliferating cell nuclear antigen (PCNA). Decreased phosphorylation levels of Akt.
化学情報
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CAS 番号 129280-34-8
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性状 Solid
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分子量 422.47
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分子式 C25H26O6
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Color White to off-white
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SMILES
O=C1C2=C(O)C(C/C=C(C)/C)=C(O)C=C2OC=C1C3=CC(C/C=C(C)/C)=C(O)C(O)=C3
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Song NR, et al. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Cancer Prev Res (Phila). 2013 Dec;6(12):1293-303. [Content Brief]
[2]. Tang S, et al. Isoangustone A induces autophagic cell death in colorectal cancer cells by activating AMPK signaling. Fitoterapia. 2021 Jul;152:104935. [Content Brief]
[3]. Li J, et al. Isoangustone A suppresses mesangial fibrosis and inflammation in human renal mesangial cells. Exp Biol Med (Maywood). 2011 Apr 1;236(4):435-44. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Isoangustone A 関連分類
HY-N4006 関連分類
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