Jinflexin A
Based on 1 Customer Validation
Jinflexin A is a phenanthrene compound that can be extracted and isolated from the roots of the plant Juncus inflexus, and it is also a potential antibacterial agent. Jinflexin A significantly inhibits the proliferation of various human tumor cell lines, with a IC50 range of 12.9 μM to 24.7 μM. Jinflexin A can be used in research related to Methicillin (HY-121544)-resistant Staphylococcus aureus infections, breast cancer, cervical cancer, and ovarian cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.00%
- CAS 番号: 2055155-75-2
- 分子式: C19H22O3
- 分子量:298.38
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
24.7 μM
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Antiproliferative activity against human HeLa cervix carcinoma cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Antiproliferative activity against human HeLa cervix carcinoma cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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33668621 |
| T47D | IC50 |
14.2 μM
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Antiproliferative activity against human T-47D ductal carcinoma cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Antiproliferative activity against human T-47D ductal carcinoma cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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27808510 |
| A2780 | IC50 |
22.3 μM
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Antiproliferative activity against human A2780 ovarian cancer cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Antiproliferative activity against human A2780 ovarian cancer cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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33668621 |
| A2780cis | IC50 |
16.9 μM
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Antiproliferative activity against human A2780cis cisplatin-resistant ovarian cancer cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Antiproliferative activity against human A2780cis cisplatin-resistant ovarian cancer cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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33668621 |
| MCF7 | IC50 |
12.9 μM
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Antiproliferative activity against human MCF-7 breast cancer cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Antiproliferative activity against human MCF-7 breast cancer cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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33668621 |
| MRC5 | IC50 |
18.9 μM
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Antiproliferative activity against human MRC-5 embryonic lung fibroblast cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Antiproliferative activity against human MRC-5 embryonic lung fibroblast cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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33668621 |
体外実験
Jinflexin A (0.1953125-100 μM; 72 h) inhibits proliferation of HeLa, HTB-26, T-47D, A2780, A2780cis, MCF-7, KCR human cancer cell lines and MRC-5 normal human fibroblasts, with the strongest activity against MCF-7 cells (IC50 = 12.9 μM) and T-47D cells (IC50 = 14.2 μM)[2].
Jinflexin A (10 mg/mL; 24 h) shows no antibacterial activity against methicillin-resistant Staphylococcus aureus (ATCC43300) in the disk-diffusion assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cervix carcinoma, HTB-26 breast adenocarcinoma, T-47D ductal carcinoma, A2780 ovarian cancer, A2780cis cisplatin-resistant ovarian cancer, MCF-7 breast cancer, KCR doxorubicin-resistant breast cancer, MRC-5 embryonic lung fibroblast
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Concentration:Two-fold serial dilution from 100 to 0.19 μM
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Incubation Time:72 h
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Result:Inhibited proliferation of HeLa cells with an IC50 of 24.7 μM.
Inhibited proliferation of HTB-26 cells with an IC50 of 22.8 μM.
Inhibited proliferation of T-47D cells with an IC50 of 14.2 μM.
Inhibited proliferation of A2780 cells with an IC50 of 22.3 μM.
Inhibited proliferation of A2780cis cells with an IC50 of 16.9 μM.
Inhibited proliferation of MCF-7 cells with an IC50 of 12.9 μM.
Inhibited proliferation of KCR cells with an IC50 of 24.2 μM.
Inhibited proliferation of MRC-5 cells with an IC50 of 18.9 μM.
化学情報
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CAS 番号 2055155-75-2
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性状 Solid
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分子量 298.38
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分子式 C19H22O3
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SMILES
OC(C(C)=C1CC2)=CC(C(OC)C)=C1C3=C2C(C)=C(O)C=C3
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Jinflexin A 関連分類
HY-N7350 関連分類
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