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製品番号: HY-P11621

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JWP24

JWP24 is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC₅₀ of 200 nM against human MAGE-A4. JWP24 binds to intracellular targets while retaining binding activity, disrupts the interaction between MAGE-A4 and RAD18, and does not induce cytotoxicity at effective concentrations. JWP24 is applicable for cancer-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₆₈H₈₉FN₁₂O₁₂S₂
分子量:1349.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

JWP24 構造式

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

RAD18

体外実験

JWP24 (0.005-80 μM; 1.5 h) potently disrupts the interaction between MAGE-A4 and RAD18 in HEK293 cells, with an IC₅₀ of 0.5 μM, and exhibits no cytotoxicity at effective concentrations^[1].
JWP24 (10 μM; 2 h) inhibits the interaction between MAGE-A4 and RAD18 in H1299 cell lysates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

H1299 cells (transiently transfected with plasmids expressing Myc-RAD18 and HA-MAGE-A4)
Concentration:

10 μM
Incubation Time:

2 h
Result:

Bound to the conserved MHD of MAGE-A4 and effectively inhibit the MAGE-A4/RAD18 interaction.

化学情報

分子量 1349.64
分子式 C₆₈H₈₉FN₁₂O₁₂S₂
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (258 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lim J, et al. Development of Next Generation Cell-Permeable Peptide Inhibitors for the Oncological Target MAGE-A4. J Med Chem. 2025;68(18):19377-19395. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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