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製品番号: HY-175422

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K-833

K-833 is a GPR119 agonist with EC₅₀ values of 39.8 nM (human), 100nM (mouse), 75.4 nM (rat) and 12.6 nM (dog). K-833 demonstrates a modest increase in GLP-1 secretion and leads to a synergistic increase in GLP-1 levels when combined with AM-5262 (HY-16619) in acute gut peptide secretion assays in mice. K-833 can be used in studies on weight loss.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2639936-77-7
分子式: C₃₀H₄₃ClFN₅O₇
分子量:640.14

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

K-833 構造式

CAS 番号: 2639936-77-7

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生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

体外実験

K-833 shows modest antagonism of the human M1 receptor (IC₅₀ = 4.5 μM), inhibition of agonist binding to the human nonselective sigma receptors (IC₅₀ = 2.7 μM) and moderate reversible inhibition of the CYP2B6 (IC₅₀ = 8.6 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	V_dss	T_1/2	C_max	F
Dog^[1]	1/2 mg/kg	p.o.	1.8 mL/min/kg	0.39 L/kg	4.7 h	0.154 μM	5 %
Mice^[1]	1/3 mg/kg	p.o.	1.5 mL/min/kg	0.42 L/kg	3.5 h	0.054 μM	1.5 %
Rat^[1]	1/5 mg/kg	p.o.	9.0 mL/min/kg	0.50 L/kg	3.8 h	0.011 μM	0.2 %

体内実験

K-833 (30 mg/kg, i.g., single dose) demonstrates a modest increase in GLP-1 secretion in acute gut peptide secretion assays in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male 10-12 week old C57BL/6J mice^[1]
Dosage:

30 mg/kg or combined with AM-5262 (HY-16619) (30 mg/kg)
Administration:

i.g. for a single dose
Result:

Led to a modest increase in GLP-1 secretion.
Led to a synergistic increase in GLP-1 levels when combined with AM-5262.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2639936-77-7
分子量 640.14
分子式 C₃₀H₄₃ClFN₅O₇
SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNCC1CN(C(CC2=CC=C(OCCCC3CCN(C4=NC=C(Cl)C=N4)CC3)C=C2F)=O)C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Moyes CR, et al. Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders. J Med Chem. 2025 Jul 24. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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