L 366509
L 366509 is a spiroindenylpiperidine camphorsulfonamide oxytocin (OT) antagonist. Modifications led to a new series of o-tolylpiperazine (TP) camphorsulfonamides, exhibiting high affinity for OT receptors and selectivity over arginine vasopressin receptors. Notably, compound 7 (L-368,899) showed excellent OT receptor affinity, potency in inhibiting OT-stimulated uterine contractions, good aqueous solubility, and oral bioavailability in multiple species. Compound 7 has entered clinical testing as an oral and intravenous tocolytic agent. Molecular modeling suggests the TP camphorsulfonamide structure mimics the D-AA2-Ile3 dipeptide, crucial in potent OT antagonists.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 138382-23-7
- 分子式: C25H33NO5S
- 分子量:459.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-17571A
Oxytocin acetate
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HY-15023
Cligosiban
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HY-14778
Retosiban
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HY-124733A
LIT-001
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HY-128351
SHR1653
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HY-108679
WAY-267464 hydrochloride
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HY-15011
L-372662
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HY-15015
OT-R antagonist 1
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HY-15015A
OT-R antagonist 2
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HY-P4895
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin
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HY-P2168
Demoxytocin
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HY-15023R
Cligosiban (Standard)
生物活性
化学情報
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CAS 番号 138382-23-7
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分子量 459.60
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分子式 C25H33NO5S
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SMILES
O=S(N(CC1)CCC21C3=CC=CC=C3C=C2)(C[C@]4(C5(C)C)CC[C@@H]5C[C@@]4(CC(O)=O)O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
L 366509 関連分類
HY-15007 関連分類
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