Lanuginosine
Based on 1 Customer Validation
Lanuginosine is an alkaloid. Lanuginosine can be isolated from the stems of Xylopia laevigata (Annonaceae) and the leaves of Magnolia grandiflora. Lanuginosine induces Apoptosis. Lanuginosine inhibits AChE (IC50: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine exhibits anticancer activity against hepatocellular carcinoma, human promyelocytic leukemia, human chronic myeloid leukemia, melanoma, and brain tumors. Lanuginosine can be used in the research of Alzheimer's disease.
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- 純度: 98.27%
- CAS 番号: 23740-25-2
- 分子式: C18H11NO4
- 分子量:305.28
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
10.9 μM (AChE)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
7.29 μM
Compound: 20
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Inhibition of LPS-induced BALB/c mouse B cell proliferation
Inhibition of LPS-induced BALB/c mouse B cell proliferation
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[PMID: 17081761] |
| HepG2 | IC50 |
0.8 μg/mL
Compound: atherospermidine
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Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
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[PMID: 11575948] |
| HepG2 2.2.15 | IC50 |
2.2 μg/mL
Compound: atherospermidine
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Cytotoxicity against human HepG2(2.2.15) cells
Cytotoxicity against human HepG2(2.2.15) cells
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[PMID: 11575948] |
| T-cell | IC50 |
4.16 μM
Compound: 20
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Inhibition of ConA-induced BALB/c mouse T cell proliferation
Inhibition of ConA-induced BALB/c mouse T cell proliferation
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[PMID: 17081761] |
Lanuginosine (72 h) shows cytotoxic activity against B16-F10, HepG2, HL-60, and K562 tumor cell lines[1].
Lanuginosine (10-20 μg/mL; 24 h) induces apoptosis in HepG2 cells[1].
Lanuginosine is cytotoxic to U251 cells (a brain tumor cell line) with an IC50 of 4 μg/mL[2].
Lanuginosine (Compound 12) is an AChE inhibitor (IC50: 10.9 μM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2
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Concentration:10 μg/mL, 20 μg/mL
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Incubation Time:24 h
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Result:Increased apoptotic cells, and significantly increased necrotic cells (AO/EB staining).
Displayed apoptotic morphology (chromatin condensation and nuclear fragmentation).
Showed significant phosphatidylserine externalization.
化学情報
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CAS 番号 23740-25-2
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性状 Solid
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分子量 305.28
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分子式 C18H11NO4
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Color Yellow to brown
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SMILES
O=C1C2=CC(OC)=CC=C2C3=C4OCOC4=CC5=CC=NC1=C53
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 0.5 mg/mL (1.64 mM; ultrasonic and warming and adjust pH to 2 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Menezes LR, et al. Cytotoxic Alkaloids from the Stem of Xylopia laevigata. Molecules. 2016 Jul 8;21(7):890. [Content Brief]
[2]. Mohamed SM, et al. Cytotoxic and antiviral activities of aporphine alkaloids of Magnolia grandiflora L. Nat Prod Res. 2010 Sep;24(15):1395-402. [Content Brief]
[3]. Jiang K, et al. Bioactive Isoquinoline Alkaloids with Diverse Skeletons from Fissistigma polyanthum. J Nat Prod. 2023 Aug 24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2757 mL | 16.3784 mL | 32.7568 mL | 81.8920 mL |
Lanuginosine 関連分類
HY-119398 関連分類
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