23740-25-2
Chemical Structure
Lanuginosine
- CAS No.: 23740-25-2
- Formula:C18H11NO4
- Molecular Weight:305.28
IUPAC Name: 10-methoxy-8H-[1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]benzo[g]quinolin-8-one
InChIKey: WLXLLQQGGGHOMA-UHFFFAOYSA-N
SMILES: O=C1C2=CC(OC)=CC=C2C3=C4OCOC4=CC5=CC=NC1=C53
Biological Activity: Lanuginosine is an alkaloid. Lanuginosine can be isolated from the stems of Xylopia laevigata (Annonaceae) and the leaves of Magnolia grandiflora. Lanuginosine induces Apoptosis. Lanuginosine inhibits AChE (IC50: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine exhibits anticancer activity against hepatocellular carcinoma, human promyelocytic leukemia, human chronic myeloid leukemia, melanoma, and brain tumors. Lanuginosine can be used in the research of Alzheimer's disease[1][2][3].
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Lanuginosine | 98.27% | Lanuginosine is an alkaloid. Lanuginosine can be isolated from the stems of Xylopia laevigata (Annonaceae) and the leaves of Magnolia grandiflora. Lanuginosine induces Apoptosis. Lanuginosine inhibits AChE (IC50: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine exhibits anticancer activity against hepatocellular carcinoma, human promyelocytic leukemia, human chronic myeloid leukemia, melanoma, and brain tumors. Lanuginosine can be used in the research of Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Menezes LR, et al. Cytotoxic Alkaloids from the Stem of Xylopia laevigata. Molecules. 2016 Jul 8;21(7):890. [Content Brief]
- [2]. Mohamed SM, et al. Cytotoxic and antiviral activities of aporphine alkaloids of Magnolia grandiflora L. Nat Prod Res. 2010 Sep;24(15):1395-402. [Content Brief]
- [3]. Jiang K, et al. Bioactive Isoquinoline Alkaloids with Diverse Skeletons from Fissistigma polyanthum. J Nat Prod. 2023 Aug 24. [Content Brief]
Keywords
