LTD4
Based on 3 publication(s) in Google Scholar
Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.5%
- CAS 番号: 73836-78-9
- 分子式: C25H40N2O6S
- 分子量:496.66
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保管条件:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Leukotriene F4Arachidonic Metabolite
MedChemExpress（MCE）の使用を引用している文献 Leukotriene D4
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Customer Validation & Images
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Cell Migration/Invasion Assay
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ELISA
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Bio/Physico-chemical Assay
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Human Endogenous Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| CHO-K1 | IC50 |
0.7 nM
Compound: LTD4
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Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins
Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins
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[PMID: 23403082] |
| Sf9 | IC50 |
5.48 μM
Compound: Leukotrien D4
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TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells
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[PMID: 11306690] |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:21-24 g, Balb/c male mice[2]
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Dosage:1.5, 3, 6, 12, 24 µg/paw
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Administration:Injected intradermally (10 µL was injected into the left hind paw)
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Result:Caused significant edematous response and dye extravasation at doses of 1.5-6 ~g/paw.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 73836-78-9
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性状 Liquid
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分子量 496.66
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分子式 C25H40N2O6S
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Color Colorless to light yellow
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SMILES
O=C(O)CNC([C@H](CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=C\C/C=C\CCCCC)N)=O
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別名
Leukotriene D4; ロイコトリエンD4
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
Publications (3)
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Journal Impact Factor
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Most Recent
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Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Cancer Cell Int
DPEP2 suppresses metastasis via NF-κB-mediated epithelial-mesenchymal transition and M2 polarization in p53-loss non-small cell lung cancer. [Abstract]2025 Nov 17;25(1):408. PMID: 41250029
Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]
The transwell and wound healing analyses of Vector/DPEP2 cells cultured with M2 CM or LTD4 (Leukotriene D4, 100 nM, 48 h).
Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]
ELISA detected the level of LTD4 in the medium of M2 cocultured with Vector/DPEP2 cells.
Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]
Total LTD4 levels in lung metastases.
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プロトコル
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
純度とドキュメンテーション
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データシート (267 KB)
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SDS (796 KB)
- English - EN (796 KB)
- Français - FR (796 KB)
- Deutsch - DE (796 KB)
- Norwegian - NO (796 KB)
- Español - ES (796 KB)
- Swedish - SV (796 KB)
- Italian - IT (796 KB)
- Korean - KR (796 KB)
- Portuguese - PT (796 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Leukotriene D4 関連分類
HY-113456 関連分類
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