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製品番号: HY-124186

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LR1143

LR1143 is a dopamine transporter (DAT) and 5-HT uptake inhibitor, with IC₅₀ values of 3.4 nM and 112 nM in rats, respectively. LR1143 binds to DAT labeled with the dopamine reuptake inhibitor GBR 12935 (HY-12242A), with an IC₅₀ of 4.4 nM. LR1143 shows lower selectivity for DAT than for serotonin reuptake sites. LR1143 can be used in studies related to cocaine abuse.

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CAS 番号: 150151-15-8
分子式: C₂₉H₃₄F₂N₂O
分子量:464.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LR1143 構造式

CAS 番号: 150151-15-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Dopamine Receptor アイソフォーム固有の製品をすべて表示 :

5-HT Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

LR1143 exhibits high affinity for rat striatal DAT (IC₅₀=4.4 nM) and inhibits [³H]DA reuptake in rat caudate nucleus (IC₅₀=3.4 nM), with 33-fold selectivity for DA reuptake sites over 5HT reuptake sites (IC₅₀=112 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

rat striatal
Concentration:

IC₅₀assay
Incubation Time:

18-24 h (DAT binding), 15 min ([3H]DA reuptake), 30 min ([3H]5HT reuptake)
Result:

Exhibited high affinity for rat striatal DAT with an IC₅₀ of 4.4 nM, inhibits [3H]DA reuptake in the rat caudate nucleus with an IC₅₀ of 3.4 nM, and demonstrates 33-fold selectivity for DA reuptake sites over 5HT reuptake sites, which have an IC₅₀ of 112 nM.

化学情報

CAS 番号 150151-15-8
分子量 464.59
分子式 C₂₉H₃₄F₂N₂O
SMILES

FC1=CC=C(C=C1)C(OCCN2CCN(CCC2)CCCC3=CC=CC=C3)C4=CC=C(C=C4)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Matecka D, et al. Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909). J Med Chem. 1996;39(24):4704-4716. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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LR1143

Dopamine Receptor アイソフォーム固有の製品をすべて表示

5-HT Receptor アイソフォーム固有の製品をすべて表示