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United States

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製品番号: HY-P12370

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LTHVVWL

LTHVVWL is a Kim-1-binding peptide. LTHVVWL functionalizes extracellular vesicles and exosomes to achieve targeted delivery to injured renal tubules. LTHVVWL modifies FRC-Exos to enhance specificity for injured renal tubules. LTHVVWL functionalizes nanoparticles for active targeting of injured kidneys. LTHVVWL is grafted onto mesoporous silica nanoparticles via a PEG linker to seal the outer layer and prevent leakage. LTHVVWL acts as a calcium chelator through hydrolysis, generating active BAPTA and reducing intracellular Ca²⁺ overload. LTHVVWL can be used for acute kidney injury research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₄₃H₆₆N₁₀O₉
分子量:867.05

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LTHVVWL 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

LTHVVWL is the preferred candidate for Kim-1 targeting due to its high binding affinity at low concentrations^[1].
LTHVVWL (5 μM; 6 h) specifically recognizes TEC overexpressing Kim-1 in vitro^[1].
LTHVVWL-anchored FRC-Exos are taken up by primary renal tubular cells in vitro, and fluorescence is observed under a confocal microscope after 24 hours of incubation, confirming this^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

分子量 867.05
分子式 C₄₃H₆₆N₁₀O₉
SMILES

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
配列

Leu-Thr-His-Val-Val-Trp-Leu
シーケンスの短縮

LTHVVWL
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Tang TT, et al. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI. Journal of the American Society of Nephrology : JASN. 2021 Oct;32(10):2467-2483.

[2]. Li Y, et al. Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury. Kidney international. 2024 Mar;105(3):508-523.

[3]. Yan J, et al. Rapidly Blocking the Calcium Overload/ROS Production Feedback Loop to Alleviate Acute Kidney Injury via Microenvironment-Responsive BAPTA-AM/BAC Co-Delivery Nanosystem. Small (Weinheim an der Bergstrasse, Germany). 2023 Apr;19(17):e2206936.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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