Lucerastat
Based on 1 Customer Validation
Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.90%
- CAS 番号: 141206-42-0
- 分子式: C10H21NO4
- 分子量:219.28
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Fabry patient-derived fibroblasts with the genotypes R301G (residual -GalA activity; 20%) R220X (<3%) and W162X (<1%).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Fabry patient-derived fibroblasts with the genotypes R301G (residual-GalA activity; 20%) R220X (<3%) and W162X (<1%).
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Concentration:
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Incubation Time:9 days.
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Result:Dose-dependently inhibited GCS, reducing glucosylceramide and increasing sphingomyelin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Fabry mice (Gla-/0 and Gla-/-, n = 5 or 6 for each gender)[2].
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Dosage:1200 mg/kg/day food admix.
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Administration:Food admix for 20 weeks.
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Result:Reduced lipid storage in two major organs affected by FD: mean Gb3 in the kidneys (-33%, p<0.01). and α-galactose- terminated glycosphingolipids in the dorsal root ganglia (-48%, p<0.05). In the liver of the Fabry mice, mean glucosylceramide (GlcCer (24:0)) was reduced (-59%, p<0.001) in addition to Gb3 (24:1) (-37%, p<0.05) demonstrating substrate reduction through GCS inhibition.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 141206-42-0
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性状 Solid
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分子量 219.28
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分子式 C10H21NO4
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Color White to yellow
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SMILES
O[C@H]1[C@@H](CO)N(CCCC)C[C@H](O)[C@H]1O
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別名
NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : 24 mg/mL (109.45 mM; ultrasonic and warming and heat to 80°C)
DMSO : 22 mg/mL (100.33 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.5604 mL | 22.8019 mL | 45.6038 mL | 114.0095 mL |
| 5 mM | 0.9121 mL | 4.5604 mL | 9.1208 mL | 22.8019 mL | |
| 10 mM | 0.4560 mL | 2.2802 mL | 4.5604 mL | 11.4009 mL | |
| 15 mM | 0.3040 mL | 1.5201 mL | 3.0403 mL | 7.6006 mL | |
| 20 mM | 0.2280 mL | 1.1401 mL | 2.2802 mL | 5.7005 mL | |
| 25 mM | 0.1824 mL | 0.9121 mL | 1.8242 mL | 4.5604 mL | |
| 30 mM | 0.1520 mL | 0.7601 mL | 1.5201 mL | 3.8003 mL | |
| 40 mM | 0.1140 mL | 0.5700 mL | 1.1401 mL | 2.8502 mL | |
| 50 mM | 0.0912 mL | 0.4560 mL | 0.9121 mL | 2.2802 mL | |
| 60 mM | 0.0760 mL | 0.3800 mL | 0.7601 mL | 1.9002 mL | |
| 80 mM | 0.0570 mL | 0.2850 mL | 0.5700 mL | 1.4251 mL | |
| 100 mM | 0.0456 mL | 0.2280 mL | 0.4560 mL | 1.1401 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lucerastat 関連分類
HY-106392 関連分類
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