LY3541860
Based on 1 Customer Validation
LY3541860 is a selective anti-CD19 antibody that both binds human CD19 with high affinity and selectively binds human B cells (Kd values: 76.8 pM and 94.5 nM for humans and cynomolgus monkeys, respectively). LY3541860 inhibits CpG-induced CD69 expression (IC50 = 0.006 nM). LY3541860 exhibits potent B cell inhibitory activities. LY3541860 can inhibit both BCR- and TLR-induced human B cell activation. LY3541860 can be used for the research of autoimmune diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: ≥99.0%
- 分子量:144.704 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Human IgG4 kappa
Human
CD19
LY3541860 (1.6-1000 nM) binds human and cynomolgus CD19 with high affinity (Kd values: 76.8 pM, 94.5 nM, respectively[1].
LY3541860 (30 minutes) selectively binds human B cells in whole blood (EC50 = 0.184 ± 0.008 nM)[1].
LY3541860 (0.001 nM-10 nM; 30 min) inhibits B cell proliferation (IC50 = 0.008 nM)[1].
LY3541860 (0.1 pM-10 nM) can inhibit CpG-induced CD69 expression (IC50 = 0.006 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (female, humanized with PBMC engraftment)[1]
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Dosage:0.01 mg/kg (IgM secretion attenuation); 1.0 mg/kg (IgM secretion attenuation and CD86 expression reduction)
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Administration:s.c.; weekly
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Result:Attenuated human IgM secretion by 60% on day 6 and 57% on day 10 at 0.01 mg/kg/week; attenuated IgM secretion by 78% on day 6 and 57% on day 10 at 1.0 mg/kg/week; reduced CD86 expression on human B cells in spleens dose-dependently
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
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Immobilized Human CD19 (20-291) Protein, His Tag can bind LY3541860. The EC50 for this effect is 100 ng/mL.
化学情報
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性状 Liquid
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分子量 144.704 kDa
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Color Colorless to off-white
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LY3541860 関連分類
HY-P991900 関連分類
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