m-PEG12-amine
Based on 1 Customer Validation
m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.71%
- CAS 番号: 1977493-48-3
- 分子式: C25H53NO12
- 分子量:559.69
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTAC Linkers アイソフォーム固有の製品をすべて表示
More
生物活性
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PEGs |
Non-cleavable Linker |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1977493-48-3
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性状 Solid
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分子量 559.69
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分子式 C25H53NO12
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Color Colorless to off-white
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SMILES
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : 100 mg/mL (178.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259. [Content Brief]
[2]. Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7867 mL | 8.9335 mL | 17.8670 mL | 44.6676 mL |
| 5 mM | 0.3573 mL | 1.7867 mL | 3.5734 mL | 8.9335 mL | |
| 10 mM | 0.1787 mL | 0.8934 mL | 1.7867 mL | 4.4668 mL | |
| 15 mM | 0.1191 mL | 0.5956 mL | 1.1911 mL | 2.9778 mL | |
| 20 mM | 0.0893 mL | 0.4467 mL | 0.8934 mL | 2.2334 mL | |
| 25 mM | 0.0715 mL | 0.3573 mL | 0.7147 mL | 1.7867 mL | |
| 30 mM | 0.0596 mL | 0.2978 mL | 0.5956 mL | 1.4889 mL | |
| 40 mM | 0.0447 mL | 0.2233 mL | 0.4467 mL | 1.1167 mL | |
| 50 mM | 0.0357 mL | 0.1787 mL | 0.3573 mL | 0.8934 mL | |
| 60 mM | 0.0298 mL | 0.1489 mL | 0.2978 mL | 0.7445 mL | |
| 80 mM | 0.0223 mL | 0.1117 mL | 0.2233 mL | 0.5583 mL | |
| 100 mM | 0.0179 mL | 0.0893 mL | 0.1787 mL | 0.4467 mL |
m-PEG12-amine 関連分類
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