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製品番号: HY-183720

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M4K2163

M4K2163 is a ALK2 inhibitor that serves as a target protein ligand for the synthesis of PROTACs, such as M4K3250 (HY-183718). M4K2163 induces cytotoxic effects in glioblastoma cells. M4K2163 can be used in the research of diffuse intrinsic pontine glioma and glioblastoma.

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CAS 番号: 2600795-21-7
分子式: C₂₄H₂₆FN₃O₂
分子量:407.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

M4K2163 構造式

CAS 番号: 2600795-21-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

ALK2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	98 nM Compound: 11b; M4K2163	Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay	[PMID: 32787083]
HEK293	IC₅₀	7475 nM Compound: 11b; M4K2163	Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual luciferase reporter assay Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual luciferase reporter assay	[PMID: 32787083]
HEK293	IC₅₀	2.5 μM Compound: 11b; M4K2163	Inhibition of human ERG expressed in HEK293 cells after 5 mins by IonWorks barracuda patch clamp method Inhibition of human ERG expressed in HEK293 cells after 5 mins by IonWorks barracuda patch clamp method	[PMID: 32787083]

体外実験

M4K2163 (96 h) reduces viability of U87-MG glioblastoma cells in a dose-dependent manner over 96 h, with cytotoxic activity independent of CRBN recruitment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2600795-21-7
分子量 407.48
分子式 C₂₄H₂₆FN₃O₂
SMILES

CC1=C(C2=CC=C(N3CCNCC3)C=C2)C=NC=C1C4=CC(OC)=C(F)C(OC)=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Webb DT, et al. Targeting Activin Receptor-like Kinase 2 Using Heterobifunctional Protein Degraders. Journal of medicinal chemistry. 2026 May 14;69(9):11524-11546. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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