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製品番号: HY-162135

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MAT2A-IN-14

MAT2A-IN-14 (compound H3) is a MAT2A inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell.

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CAS 番号: 3032026-05-1
分子式: C₂₇H₂₄F₂N₄O₄
分子量:506.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

MAT2A-IN-14 構造式

CAS 番号: 3032026-05-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.35 μM Compound: H3	Antiproliferative activity against MTAP knocked out human HCT-116 cells incubated for 5 days by MTT method Antiproliferative activity against MTAP knocked out human HCT-116 cells incubated for 5 days by MTT method	[PMID: 38166392]
HCT-116	IC₅₀	42 nM Compound: H3	Antiproliferative activity against MTAP knocked out human HCT-116 cells under 4 mins sonication Antiproliferative activity against MTAP knocked out human HCT-116 cells under 4 mins sonication	[PMID: 38166392]
HCT-116	IC₅₀	79 nM Compound: H3	Antiproliferative activity against MTAP knocked out human HCT-116 cells under 1 min sonication Antiproliferative activity against MTAP knocked out human HCT-116 cells under 1 min sonication	[PMID: 38166392]

化学情報

CAS 番号 3032026-05-1
分子量 506.50
分子式 C₂₇H₂₄F₂N₄O₄
SMILES

O=C1C(C2=CC=C(C3=C2)OCC4N3CCC4)=CC(C=NC(OCC)=N5)=C5N1C6=CC=C(C=C6)OC(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. He H, et al. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis. J Med Chem. 2024;67(1):543-554. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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