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United States

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製品番号: HY-187426

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MDOLL-0591

MDOLL-0591 is a selective CHIKV nsP3 macrodomain inhibitor and antiviral agent, with an IC₅₀ of 10 μM against CHIKV nsP3. MDOLL-0591 inhibits the replication of CHIKV in cell culture systems. MDOLL-0591 is applicable to research related to Chikungunya virus infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₀H₁₇N₃O₃S
分子量:379.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MDOLL-0591 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	EC50	0.5 μM	Inhibition of CHIKV replication in human embryonic kidney HEK-293T cells assessed via NanoLuc luciferase activity at 20 hours post-infection with CHIKV-nLuc at MOI 0.05, with parallel ATP-based cell viability measurements confirming no significant cytotoxicity at tested concentrations. Inhibition of CHIKV replication in human embryonic kidney HEK-293T cells assessed via NanoLuc luciferase activity at 20 hours post-infection with CHIKV-nLuc at MOI 0.05, with parallel ATP-based cell viability measurements confirming no significant cytotoxicity at tested concentrations.	42531898

体外実験

MDOLL-0591 (0.003-100 μM) potently inhibits ADP-ribosyl binding activity of the purified CHIKV nsP3 macrodomain with an IC₅₀ of 10 μM^[1].
MDOLL-0591 (12.5-50 μM; 16 h) inhibits CHIKV replication in BHK-21 cells in vitro in a concentration-dependent manner, reducing viral replication by nearly 70% at 50 μM without causing cytotoxicity^[1].
MDOLL-0591 (12.5-50 μM; 20 h) potently inhibits CHIKV replication in HEK-293T cells with an EC₅₀ of 0.5 μM, reducing viral replication by 97% at 50 μM without causing cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 379.43
分子式 C₂₀H₁₇N₃O₃S
SMILES

O=C(N1C(C)=C(C)C2=C1C=CC3=CC=CC=C23)CSC4=NC(O)=CC(O)=N4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Duong MTH, et al. Discovery of thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket. European journal of medicinal chemistry. 2026 Jul 22;318:119182.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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