country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-187989

Copy Link Print Information

ME67

Name: ME67
Brand: MedChemExpress
SKU: HY-187989
Availability: PreOrder

(別名: EM-B enol ether)

ME67 (EM-B enol ether) is a motilin receptor (Motilin Receptor) agonist with pIC₅₀ values of 8.38 and 6.49 for rabbit and human motilin receptors, respectively. ME67 activates the G protein-coupled Motilin Receptor, inducing calcium mobilization, calcium flux, receptor internalization, and gastrointestinal motility. ME67 can be used in research on gastrointestinal motility disorders.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 33275-72-8
分子式: C₃₇H₆₅NO₁₁
分子量:699.91

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ME67 構造式

CAS 番号: 33275-72-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

ME67 (EM-B enol ether) (10 μM; 1 h) induces receptor desensitization in CHO cells stably expressing the human motilin receptor^[2].
ME67 induces calcium ion release in CHO-K1 cells expressing the human motilin receptor, with a pEC₅₀ of 8.12^[1].
ME67 contracts rabbit duodenal segments with a pEC₅₀ of 7.11 and binds to rabbit antral motilin receptors with a pIC₅₀ of 8.38^[1].
ME67 activates Ca²⁺ flux in CHO-K1 cells expressing human MTLR and apoaequorin, with a pEC₅₀ of 8.12, and desensitizes the subsequent motilin response with a pDC₅₀ of 6.03^[2].
ME67 (10⁻¹²-10⁻⁴ M; 60 min) binds to the human motilin receptor in CHO-MTLR membranes with a pIC₅₀ of 6.49^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Ca²⁺ Staining Technique

化学情報

CAS 番号 33275-72-8
分子量 699.91
分子式 C₃₇H₆₅NO₁₁
SMILES

C[C@]1(OC([C@@H]([C@H]([C@H]([C@H](OC([C@@H]([C@H]([C@@H]2C)O[C@H]3C[C@](C)([C@H]([C@@H](O3)C)O)OC)C)=O)CC)C)O)C)=C(C1)C)[C@@H]2O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O
別名

EM-B enol ether
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Thielemans L, et al. The motilin pharmacophore in CHO cells expressing the human motilin receptor. Biochemical and biophysical research communications. 2002 May 17;293(4):1223-7. [Content Brief]

[2]. Thielemans L, et al. Desensitization of the human motilin receptor by motilides. The Journal of pharmacology and experimental therapeutics. 2005 Jun;313(3):1397-405. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ