Merbarone (Standard)
Merbarone (Standard) is the analytical standard of Merbarone. This product is intended for research and analytical applications. Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 97534-21-9
- 分子式: C11H9N3O3S
- 分子量:263.27
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
化学情報
- 純度とドキュメンテーション
-
Help & FAQs
-
HY-19024
MerbaroneTopoisomerase II Inhibitor -
HY-13761
TeniposideTopoisomerase Inhibitor -
HY-13502A
Mitoxantrone dihydrochlorideTop II/PKC Inhibitor -
HY-13631
ExatecanTopoisomerase I Inhibitor -
HY-13761R
Teniposide (Standard)Topoisomerase Inhibitor -
HY-16560
CamptothecinTopo I inhibitor -
HY-13631A
Exatecan mesylateTopoisomerase I Inhibitor -
HY-13631R
Exatecan (Standard)Topoisomerase I Inhibitor -
HY-B0268
EnoxacinBacterial Inhibitor -
HY-15753
EllipticineTopoisomerase Inhibitor -
HY-16742
GepotidacinAntibacterial Agent -
HY-100309
9-AminocamptothecinTopoisomerase I Inhibitor
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
-
CAS 番号 97534-21-9
-
分子量 263.27
-
分子式 C11H9N3O3S
-
SMILES
O=C(C(C(N1)=O)C(NC1=S)=O)NC2=CC=CC=C2
-
別名
NSC 336628 (Standard)
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Fortune JM, et, al. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. J Biol Chem. 1998 Jul 10;273(28):17643-50. [Content Brief]
[2]. Brewer AD, et, al. 5-(N-phenylcarboxamido)-2-thiobarbituric acid (NSC 336628), a novel potential antitumor agent. Biochem Pharmacol. 1985 Jun 1;34(11):2047-50. [Content Brief]
[3]. Cooney DA, et, al. Initial mechanistic studies with merbarone (NSC 336628). Biochem Pharmacol. 1985 Sep 15;34(18):3395-8. [Content Brief]
[4]. Chen M, et, al. Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26. Cancer Res. 1995 Apr 1;55(7):1509-16. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Merbarone (Standard) 関連分類
HY-19024R 関連分類
Powered by Bioz