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製品番号: HY-158073

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ML2006a4

ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (M^pro) with IC₅₀ in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2943213-62-3
分子式: C₃₀H₄₄F₃N₅O₆
分子量:627.70

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

ML2006a4 構造式

CAS 番号: 2943213-62-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

ML2006a4 (0-10 μM) reveals an antiviral activity in cells Huh7.5.1++ and A549-ACE2 (A549+), with EC₅₀s of 100 and 120 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

ML2006a4 (20 mg/kg, i.v.) reveals a pharmacokinetic profils with an oral bioavailability of 27% (40 mg/kg, p.o.) and a plasma clearance rate C_pl of 39 mL/min/kg and Volume of distribution at steady state V_ss 0.66 L/kg^[1].
ML2006a4 (40 mg/kg, p.o., twice a day for 4 days) ameliorates the SARS-CoV-2 infection, exhibits viral inhibitory and lung protective efficacy in BALB/c mice without significant toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SARS-CoV-2 MA10 infected BALB/c mice^[1]
Dosage:

40 mg/kg
Administration:

p.o., twice a day for 4 days
Result:

Reduced inflammation and respioratory epithelial injury, improved epithelial regeneration and the survival rates with minimal weight loss.

化学情報

CAS 番号 2943213-62-3
分子量 627.70
分子式 C₃₀H₄₄F₃N₅O₆
SMILES

O=C([C@@H]1[C@@]2([H])C(C)(C)[C@@]2([H])CN1C([C@@H](NC(C(F)(F)F)=O)C(C)(C)C)=O)N[C@H](C(C(N3CC(C)(C)C3)=O)=O)C[C@H]4C(NCCC4)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Westberg M, et al., An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Sci Transl Med. 2024 Mar 13;16(738):eadi0979. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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