MM11253
Based on 1 Customer Validation
MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.21%
- CAS 番号: 345952-44-5
- 分子式: C28H30O2S2
- 分子量:462.67
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.06 μM
Compound: 15b
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Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase
Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase
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[PMID: 26918322] |
| Sf9 | IC50 |
1.03 μM
Compound: 15b
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Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
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[PMID: 26918322] |
MM11253 blocks the ability of MM11254 and MM11389 to inhibit squamous cell carcinoma cell growth[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 345952-44-5
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性状 Solid
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分子量 462.67
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分子式 C28H30O2S2
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=C2C=C(C3(C4=CC=C5C(C)(C)CCC(C)(C)C5=C4)SCCS3)C=CC2=C1)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (270.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. M I Dawson, et al. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Int J Cancer. 2001 Jan 1;91(1):8-21. [Content Brief]
[2]. Q Le, et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19(11):1457-65. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1614 mL | 10.8068 mL | 21.6137 mL | 54.0342 mL |
| 5 mM | 0.4323 mL | 2.1614 mL | 4.3227 mL | 10.8068 mL | |
| 10 mM | 0.2161 mL | 1.0807 mL | 2.1614 mL | 5.4034 mL | |
| 15 mM | 0.1441 mL | 0.7205 mL | 1.4409 mL | 3.6023 mL | |
| 20 mM | 0.1081 mL | 0.5403 mL | 1.0807 mL | 2.7017 mL | |
| 25 mM | 0.0865 mL | 0.4323 mL | 0.8645 mL | 2.1614 mL | |
| 30 mM | 0.0720 mL | 0.3602 mL | 0.7205 mL | 1.8011 mL | |
| 40 mM | 0.0540 mL | 0.2702 mL | 0.5403 mL | 1.3509 mL | |
| 50 mM | 0.0432 mL | 0.2161 mL | 0.4323 mL | 1.0807 mL | |
| 60 mM | 0.0360 mL | 0.1801 mL | 0.3602 mL | 0.9006 mL | |
| 80 mM | 0.0270 mL | 0.1351 mL | 0.2702 mL | 0.6754 mL | |
| 100 mM | 0.0216 mL | 0.1081 mL | 0.2161 mL | 0.5403 mL |
MM11253 関連分類
HY-108530 関連分類
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