NAADP
NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling.
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- CAS 番号: 5502-96-5
- 分子式: C21H27N6O18P3
- 分子量:744.39
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
NAADP (2.5-10 μM) induces Ca2+ release from acidic intracellular stores in cytotoxic T lymphocytes[2].
NAADP (10 μM, 30 min) stimulates cytolytic granule exocytosis in cytotoxic T lymphocyte[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS/GalN induced liver injury mice model[3]
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Dosage:0.181 mg/kg
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Administration:i.v.
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Result:Promoted autophagosome formation in in hepatocytes.
Showed higher levels of LC3II, p62, ATG5, and ATG7 in hepatocytes.
化学情報
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CAS 番号 5502-96-5
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性状 Solid
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分子量 744.39
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分子式 C21H27N6O18P3
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Color White to off-white
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SMILES
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OC[C@H]4O[C@@H]([N+]5=CC(C(O)=O)=CC=C5)[C@H](O)[C@@H]4O)(O)=O)(O)=O)[C@@H](O)[C@H]3OP(O)([O-])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : 50 mg/mL (67.17 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326. [Content Brief]
[2]. Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22(24):2331-7. [Content Brief]
[3]. Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31(7):3126-3137. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3434 mL | 6.7169 mL | 13.4338 mL | 33.5845 mL |
| 5 mM | 0.2687 mL | 1.3434 mL | 2.6868 mL | 6.7169 mL | |
| 10 mM | 0.1343 mL | 0.6717 mL | 1.3434 mL | 3.3585 mL | |
| 15 mM | 0.0896 mL | 0.4478 mL | 0.8956 mL | 2.2390 mL | |
| 20 mM | 0.0672 mL | 0.3358 mL | 0.6717 mL | 1.6792 mL | |
| 25 mM | 0.0537 mL | 0.2687 mL | 0.5374 mL | 1.3434 mL | |
| 30 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1195 mL | |
| 40 mM | 0.0336 mL | 0.1679 mL | 0.3358 mL | 0.8396 mL | |
| 50 mM | 0.0269 mL | 0.1343 mL | 0.2687 mL | 0.6717 mL | |
| 60 mM | 0.0224 mL | 0.1119 mL | 0.2239 mL | 0.5597 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NAADP 関連分類
HY-103317 関連分類
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