Narsoplimab
Based on 1 publication(s) in Google Scholar
Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.45%
- CAS 番号: 2108782-45-0
- 分子量:143.1 kDa
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保管条件:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
MedChemExpress(MCE)の使用を引用している文献 Narsoplimab
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生物活性
製品説明
Isotype
Human IgG4 lambda
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
MASP2
体外実験
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT and Masp2-/- (KO) mice (C57BL/6N, female, 12-15 weeks old)[1]
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Dosage:10 mg/kg
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Administration:Intravenous injection
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Result:Decreased percentage of lymphocytes (Lym%) and an increased percentage of neutrophils (Neu%).
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 lambda
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized MASP2 Protein, Human (His) can bind Narsoplimab. The EC50 for this effect is 12.79 ng/mL.
化学情報
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CAS 番号 2108782-45-0
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性状 Liquid
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分子量 143.1 kDa
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Color Colorless to light yellow
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SMILES
[Narsoplimab]
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別名
OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Blood Adv
CG001, a C3b-targeted complement inhibitor blocks three complement pathways: development and preclinical evaluation. [Abstract]2024 Aug 13;8(15):4181-4193. PMID: 38865712
純度とドキュメンテーション
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データシート (262 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)