NC-R17
NC-R17 is a PROTAC degrader that targets glutathione peroxidase 4 (GPX4) for degradation by recruiting cereblon. With RSL3 as its parent core, NC-R17 binds non-covalently to GPX4. NC-R17 exhibits moderate GPX4 degradation activity in tumor cells and can be used in studies related to ferroptosis (ferroptosis) and tumors.
(Pink: GPX4 ligand (HY-135832); Blue: Cereblon ligand (HY-A0003); Black: linker (HY-169376)).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3049087-34-2
- 分子式: C53H67N7O7
- 分子量:914.14
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
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GPX4 |
NC-R17 (0.1-20 μM; 24 h) induces moderate GPX4 protein degradation in HT1080 cells when treated at 20 μM or 10 μM for 24 h, with no detectable degradation at lower concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT1080 human fibrosarcoma cells
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Concentration:0.1 μM, 1 μM, 10 μM, 20 μM
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Incubation Time:24 h
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Result:Reduced GPX4 protein levels to 59% of the control level.
Reduced GPX4 protein levels to 68% of the control level.
Did not reduce GPX4 protein levels (levels were 106% of the control).
Did not reduce GPX4 protein levels (levels were 88% of the control).
化学情報
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CAS 番号 3049087-34-2
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分子量 914.14
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分子式 C53H67N7O7
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SMILES
O=C(OC)[C@@H]1N(C(CC)=O)[C@@H](C2=CC=C(C(N3CCN(CCCCCCCCCCCCCNC4=C(CN(C5C(NC(CC5)=O)=O)C6=O)C6=CC=C4)CC3)=O)C=C2)C7=C(C(C=CC=C8)=C8N7)C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NC-R17 関連分類
HY-155075 関連分類
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