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United States

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製品番号: HY-125084

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NEU617

NEU617 is an anti-parasite agent. NEU617 inhibits the proliferation for the HAT (human African trypanosomiasis) pathogen (EC₅₀: 42 nM for Trypanosoma brucei, 1.8 μM for T. cruzi). NEU617 is a derivative of Lapatinib (HY-50898).

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CAS 番号: 1432450-82-2
分子式: C₃₁H₂₆ClFN₄O₂
分子量:541.02

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NEU617 構造式

CAS 番号: 1432450-82-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
3T3	EC₅₀	1.8 μM Compound: 4; NEU-617	Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in rat 3T3 cells after 48 hrs by chlorophenol red-beta-D-galactopyranoside based assay Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in rat 3T3 cells after 48 hrs by chlorophenol red-beta-D-galactopyranoside based assay	[PMID: 28337329]
HepG2	IC₅₀	>20 μM Compound: 23a, NEU617	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 23597080]
RAW264.7	EC₅₀	>8 μM Compound: 4; NEU-617	Antileishmanial activity against luciferase-expressing Leishmania major amastigotes infected in mouse RAW264.7 cells after 96 hrs by luminescence assay Antileishmanial activity against luciferase-expressing Leishmania major amastigotes infected in mouse RAW264.7 cells after 96 hrs by luminescence assay	[PMID: 28337329]
RAW264.7	EC₅₀	8 μM Compound: 1	Antiparasite activity against luciferase-expressing Leishmania major amastigotes isolated from infected in mouse RAW264.7 cells assessed as growth inhibition incubated for 96 hrs by luciferase reporter gene assay Antiparasite activity against luciferase-expressing Leishmania major amastigotes isolated from infected in mouse RAW264.7 cells assessed as growth inhibition incubated for 96 hrs by luciferase reporter gene assay	[PMID: 26087257]

化学情報

CAS 番号 1432450-82-2
分子量 541.02
分子式 C₃₁H₂₆ClFN₄O₂
SMILES

FC1=CC(COC2=CC=C(NC3=C4C=C(C5=CC=CC(N6CCOCC6)=C5)C=CC4=NC=N3)C=C2Cl)=CC=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Devine W, et al. Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery. J Med Chem. 2015 Jul 23;58(14):5522-37. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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