NIOCH 14
NIOCH 14 is a antiviral agent and a pro-agent. NIOCH 14 has antiviral activity against orthopoxviruses. NIOCH 14 can significantly lower proportions of infected mice, and virus production levels in the lungs. NIOCH 14 can be used for researching anti-smallpox. NIOCH 14 shows anti-orthopoxvirus activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1268015-38-8
- 分子式: C19H17F3N2O4
- 分子量:394.34
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
Orthopoxviruses[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
1193.4 μM
Compound: NIOCH-14
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Cytotoxicity against African green monkey Vero cells measured after 4 days by colorimetric assay
Cytotoxicity against African green monkey Vero cells measured after 4 days by colorimetric assay
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[PMID: 36414175] |
| Vero | EC50 |
0.011 μg/mL
Compound: 58; NIOCH-14
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Antiviral activity against ectromelia virus K-1 infected in Vero cells measured after 4 days by colorimetric assay
Antiviral activity against ectromelia virus K-1 infected in Vero cells measured after 4 days by colorimetric assay
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[PMID: 36961984] |
| Vero | EC50 |
0.013 μg/mL
Compound: 58; NIOCH-14
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Antiviral activity against Monkeypox virus V79-1-005 infected in Vero cells measured after 4 days by colorimetric assay
Antiviral activity against Monkeypox virus V79-1-005 infected in Vero cells measured after 4 days by colorimetric assay
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[PMID: 36961984] |
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1268015-38-8
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分子量 394.34
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分子式 C19H17F3N2O4
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SMILES
O=C(C1C2C=CC(C3CC23)C1C(NNC(C4=CC=C(C(F)(F)F)C=C4)=O)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Sokolova AS, et al. (+)-Camphor and (-)-borneol derivatives as potential anti-orthopoxvirus agents. Arch Pharm (Weinheim). 2021;354(6):e2100038. [Content Brief]
[2]. Mazurkov OY, et al. New effective chemically synthesized anti-smallpox compound NIOCH-14. J Gen Virol. 2016;97(5):1229-1239. [Content Brief]
[3]. Anastasiya S Sokolova, et al. (+)-Camphor and (-)-borneol derivatives as potential anti-orthopoxvirus agents. Arch Pharm (Weinheim). 2021 Jun;354(6):e2100038. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NIOCH 14 関連分類
HY-147016 関連分類
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