NITD-688
Based on 1 Customer Validation
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.04%
- CAS 番号: 2407227-31-8
- 分子式: C25H32N4O3S2
- 分子量:500.68
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
NS4B[1]
NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM[1].
NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM[1].
NITD-688 directly binds to wild-type but not mutant NS4B protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Infected AG129 mice[1]
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Dosage:30 mg/kg
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Administration:Oral gavage, twice daily for 3 days
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Result:Resulted in a 1.16-log reduction in viremia.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2407227-31-8
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性状 Solid
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分子量 500.68
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分子式 C25H32N4O3S2
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Color White to off-white
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SMILES
N#CC(C(CN1CC2CCCCC2)=C(CC(C)1C)S3)=C3NC(CC(C=C4)=CC=C4[S](N)(=O)=O)=O
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別名
EYU-688
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (199.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9973 mL | 9.9864 mL | 19.9728 mL | 49.9321 mL |
| 5 mM | 0.3995 mL | 1.9973 mL | 3.9946 mL | 9.9864 mL | |
| 10 mM | 0.1997 mL | 0.9986 mL | 1.9973 mL | 4.9932 mL | |
| 15 mM | 0.1332 mL | 0.6658 mL | 1.3315 mL | 3.3288 mL | |
| 20 mM | 0.0999 mL | 0.4993 mL | 0.9986 mL | 2.4966 mL | |
| 25 mM | 0.0799 mL | 0.3995 mL | 0.7989 mL | 1.9973 mL | |
| 30 mM | 0.0666 mL | 0.3329 mL | 0.6658 mL | 1.6644 mL | |
| 40 mM | 0.0499 mL | 0.2497 mL | 0.4993 mL | 1.2483 mL | |
| 50 mM | 0.0399 mL | 0.1997 mL | 0.3995 mL | 0.9986 mL | |
| 60 mM | 0.0333 mL | 0.1664 mL | 0.3329 mL | 0.8322 mL | |
| 80 mM | 0.0250 mL | 0.1248 mL | 0.2497 mL | 0.6242 mL | |
| 100 mM | 0.0200 mL | 0.0999 mL | 0.1997 mL | 0.4993 mL |
NITD-688 関連分類
HY-138543 関連分類
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