NPD8790
NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 615281-26-0
- 分子式: C20H24N2
- 分子量:292.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
NPD8790 shows marks species selectivity, inhibiting C. elegans complex I (IC50 = 2.4 µM) more potently than complex I from either bovine (IC50 = 27.2 µM), murine heart mitochondria (IC50 = 28.8 µM) or human mitochondria (IC50 > 75 μM)[1].
NPD8790 against complex I is similar for all nematode species (C. briggsae, IC50 = 1.6 μM; P. pacificus, IC50 = 2.1 μM; P. hermaphrodita, IC50 = 1.1 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 615281-26-0
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分子量 292.42
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分子式 C20H24N2
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SMILES
CC(CC1=CC=C(C=C1)C(C2=NC3=C(N2C)C=CC=C3)C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NPD8790 関連分類
HY-158423 関連分類
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