NS-8
NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 186033-14-7
- 分子式: C12H10FN3
- 分子量:215.23
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:1, 3 and 10 mg/kg
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Administration:Intraduodenal administration, intravenous injection
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Result:Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure).
Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude.
Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.
化学情報
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CAS 番号 186033-14-7
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分子量 215.23
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分子式 C12H10FN3
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SMILES
CC1=C(C2=C(F)C=CC=C2)NC(N)=C1C#N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NS-8 関連分類
HY-147383 関連分類
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