P-CAB agent 1
P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2374139-68-9
- 分子式: C26H23FN4O
- 分子量:426.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 60.50 nM (H+/K+-ATPase)[1]
Pharmacokinetic Parameters of P-CAB agent 1 in female Sprague-Dawley rats[1].
| IV (2 mg/kg) | PO (8 mg/kg) | |
| AUC0-∞ (ug/L*hr) | 519.57 | 341.49 |
| t1/2 (ng/mL) | 0.49 | 0.8 |
| Cmax (ug/L) | 149.93 | 17 |
| F (%) | 16.43 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2374139-68-9
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分子量 426.49
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分子式 C26H23FN4O
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SMILES
O=C(N)C1=CC(C2=CC=CC(CN3N=C4CN(CC4=C3C5=CC=CC=C5F)C)=C2)=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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