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製品番号: HY-P3384

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Pezadeftide

Name: Pezadeftide
Brand: MedChemExpress
SKU: HY-P3384
Availability: PreOrder

(別名: HXP124)

Pezadeftide (HXP124) is a naturally derived plant defensin peptide molecule with antifungal activity. Pezadeftide binds to fungal cell wall chitin and β-glucan, enters fungal cells via endocytosis; induces mitochondrial membrane hyperpolarization, promotes ROS generation, further triggers vacuole fusion, alters plasma membrane permeability, and ultimately causes fungal cell death. Pezadeftide exhibits inhibitory effects against various skin and nail pathogenic fungi. Pezadeftide can be used in research related to fungal infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1907724-92-8
分子式: C₂₃₄H₃₇₂N₇₀O₆₆S₈
分子量:5478.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pezadeftide 構造式

CAS 番号: 1907724-92-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Fungal InfectionBacterial InfectionMitochondrial FunctionOxidative Stress

Fungal Infection

Pezadeftide exhibits inhibitory activity against multiple skin and nail pathogenic fungi; for Trichophyton rubrum IC₅₀ = 4.6 μg/mL, for Trichophyton mentagrophytes IC₅₀ = 8.4 μg/mL, for Candida auris IC₅₀ = 1.3 μg/mL, for Candida albicans IC₅₀ = 3.4 μg/mL, for Candida tropicalis IC₅₀ = 1.9 μg/mL^[1].
Pezadeftide selects resistant S. cerevisiae deletion strains enriched in mitochondrial respiration and sphingolipid biosynthesis, among which F1-F0 ATP synthase mutants exhibit higher tolerance^[2].
Pezadeftide permeabilizes the S. cerevisiae plasma membrane in a concentration-dependent manner, induces ROS, and hyperpolarizes the mitochondrial membrane potential in S. cerevisiae BY4741^[2].
Pezadeftide induces ROS at 3-7 min and triggers vacuolar fusion at 14-16 min^[2].

Fungal Infection

Bacterial Infection

Pezadeftide (Ppdef1) binds chitin and yeast β-glucan in cell-free polysaccharide-binding assays and inhibits fungal pathogens with IC₅₀ values of 1.3-42.7 µg/mL, showing no activity against the tested bacteria at concentrations up to 200 µg/mL^[2].

Fungal Infection

Mitochondrial Function

Pezadeftide (15 μM) induces mitochondrial membrane hyperpolarization in C. albicans/S. cerevisiae and binds/internalizes in T. rubrum, accompanied by increased mitochondrial membrane potential^[1].

Oxidative Stress

Fungal Infection

Pezadeftide induces ROS in C. albicans cells and increases ROS production in T. rubrum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 1907724-92-8
分子量 5478.41
分子式 C₂₃₄H₃₇₂N₇₀O₆₆S₈
別名

HXP124
配列

Ala-Lys-Val-Cys-Thr-Lys-Pro-Ser-Lys-Phe-Phe-Lys-Gly-Leu-Cys-Gly-Thr-Asp-Gly-Ala-Cys-Thr-Thr-Ala-Cys-Arg-Lys-Glu-Gly-Leu-His-Ser-Gly-Tyr-Cys-Gln-Leu-Lys-Gly-Phe-Leu-Asn-Ser-Val-Cys-Val-Cys-Arg-Lys-His-Cys (Disulfide bridge:Cys4-Cys51,Cys15-Cys35,Cys21-Cys45,Cys25-Cys47)
シーケンスの短縮

AKVCTKPSKFFKGLCGTDGACTTACRKEGLHSGYCQLKGFLNSVCVCRKHC (Disulfide bridge:Cys4-Cys51,Cys15-Cys35,Cys21-Cys45,Cys25-Cys47)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (331 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Van der Weerden NL, et al. Pezadeftide is a potent antifungal peptide with rapid fungicidial activity via a unique mechanism of action. J Am Acad Dermatol. 2022 Sep 1;87:Ab92.

[2]. Parisi K, et al. Hyperpolarisation of Mitochondrial Membranes Is a Critical Component of the Antifungal Mechanism of the Plant Defensin, Ppdef1. Journal of fungi (Basel, Switzerland). 2024 Jan 07;10(1):54.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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生物活性
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Pezadeftide

生物活性

製品説明

体外実験

化学情報

純度とドキュメンテーション

参考文献

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Pezadeftide

生物活性

製品説明

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

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