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製品番号: HY-P992553

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PF-07257876

PF-07257876 is a CD47/PD‑L1 bispecific antibody that preferentially targets tumor cells through high PD-L1 affinity and weak CD47 affinity. PF‑07257876 simultaneously blocks the CD47‑SIRPα innate immune checkpoint and the PD‑L1/PD‑1 adaptive immune checkpoint, activates dendritic cells and macrophages, enhances CD8⁺ T cell infiltration within the tumor microenvironment, and synergistically mobilizes innate and adaptive immunity to exert antitumor effects. PF-07257876 can be used in research on CD47/PD‑L1-related cancers, such as ovarian cancer and non-small cell lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PF-07257876 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- Target
- Conjugated
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Species Reactivity

Human

体外実験

PF-07257876 exhibits high affinity for PD-L1 and weaker affinity for CD47, thereby achieving tumor-biased targeting and reducing off-target binding to red blood cells^[1]^[2].
PF‑07257876 can dually inhibit the CD47‑SIRPα and PD‑L1‑PD‑1 immune checkpoint axes, activate dendritic cells and macrophages, enhance CD8⁺ T cell infiltration in the tumor microenvironment, and generate an innate‑adaptive combined antitumor immune response^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Target

CD47 & PDL1

Conjugated

Unconjugated

アプリケーション

ELISA, FACS, Functional assay

化学情報

SMILES

[PF- 07257876]
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Luo X, et al. Blocking CD47-SIRPα Signal Axis as Promising Immunotherapy in Ovarian Cancer. Cancer control : journal of the Moffitt Cancer Center. 2023;30:10732748231159706.

[2]. Jiang C, et al. Targeting the CD47/SIRPα pathway in malignancies: recent progress, difficulties and future perspectives. Frontiers in oncology. 2024;14:1378647.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- Target
- Conjugated
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
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PF-07257876

生物活性