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製品番号: HY-184029

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PF-7845yne

PF-7845yne is a clickable analogue of PF-7845. PF-7845yne serves as a pharmacological probe to investigate effects of targeting the FAAH-anandamide pathway.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1020321-13-4
分子式: C₂₇H₂₇N₅O₃
分子量:469.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

PF-7845yne 構造式

CAS 番号: 1020321-13-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PF-7845yne is a clickable analogue of PF-7845. PF-7845yne serves as a pharmacological probe to investigate effects of targeting the FAAH-anandamide pathway^[1].

体外実験

PF-7845yne (0.1-10000 nM; 30 min) potently and selectively inhibits mouse brain membrane FAAH, mirroring the activity of its parent compound PF-7845, with no activity against MAGL or ABHD6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

PF-7845yne (0.01-12.5 mg/kg; i.p.; single dose) potently and selectively inhibits brain FAAH activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57Bl/6J mice^[1]
Dosage:

0.01; 0.05; 0.25; 1.25; 6.25; 12.5 mg/kg
Administration:

i.p.; single dose
Result:

Completely inhibited brain fatty acid amide hydrolase (FAAH) activity at doses as low as 0.05 mg/kg.
Confirmed complete selectivity toward FAAH in mouse brain membrane and soluble proteomes, with no detectable off-target labeling at any tested dose.

化学情報

CAS 番号 1020321-13-4
分子量 469.53
分子式 C₂₇H₂₇N₅O₃
SMILES

O=C(N1CC/C(CC1)=C\C2=CC(OC3=NC=C(C=C3)OCCCC#C)=CC=C2)NC4=NN=CC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Niphakis MJ, et al. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci. 2012;3(5):418-426. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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