Pilsicainide
Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent.
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- CAS 番号: 88069-67-4
- 分子式: C17H24N2O
- 分子量:272.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment[1]
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Dosage:2 mg/kg
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Administration:Bolus injection into right external carotid vein within 2 minutes, once
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Result:Elongated the QT interval at 15 and 60 minutes after administration.
Shortened P wave and QRS complex durations.
Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.
化学情報
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CAS 番号 88069-67-4
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分子量 272.39
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分子式 C17H24N2O
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SMILES
O=C(NC1=C(C)C=CC=C1C)CC23CCCN2CCC3
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別名
SUN 1165 free base; Pilzicainide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pilsicainide 関連分類
HY-133715 関連分類
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