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製品番号: HY-N20751

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Planispine A

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1202761-42-9
分子式: C₂₅H₃₀O₆
分子量:426.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

Planispine A 構造式

CAS 番号: 1202761-42-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC50	21.38 μM	Antiproliferative activity against human HeLa cancer cells assessed as reduction in cell viability using CellTiter 96 AQueous One Solution assay with 16 h pre-incubation of planispine A. Antiproliferative activity against human HeLa cancer cells assessed as reduction in cell viability using CellTiter 96 AQueous One Solution assay with 16 h pre-incubation of planispine A.	36364114
HeLa	IC50	3.9 μM	Antiproliferative activity against human HeLa cancer cells in combination with 25 μM cisplatin, assessed as reduction in cell viability using CellTiter 96 AQueous One Solution assay with 16 h pre-incubation of planispine A. Antiproliferative activity against human HeLa cancer cells in combination with 25 μM cisplatin, assessed as reduction in cell viability using CellTiter 96 AQueous One Solution assay with 16 h pre-incubation of planispine A.	36364114

体外実験

Anti-cancerApoptosisCell Cycle Regulation

Anti-cancer

Planispine A (2-40 μM; 16 h) inhibits the proliferation of HeLa cells in a dose-dependent manner, with an IC₅₀ of 21.38 μM; meanwhile, this compound synergistically enhances the antiproliferative effect of Cisplatin (HY-17394). When combined with 25 μM Planispine A, the IC₅₀ of Cisplatin alone decreases to 3.9 μM^[1].
Planispine A (5-10 μM; 16 h) inhibits the Fanconi anemia pathway in HeLa cells by reducing cisplatin-induced FANCD2 foci formation and monoubiquitination modification, with monoubiquitination completely blocked at a concentration of 10 μM^[1].

Anti-cancer

Apoptosis

Planispine A (5-10 μM; 16-64 h) enhances cisplatin-induced apoptotic death of HeLa cells via a caspase-dependent mechanism, which is evidenced by increased formation of apoptotic nuclei and enhanced cleavage of caspase-3 and PARP^[1].

Anti-cancer

Cell Cycle Regulation

Combination treatment with Planispine A (3-10 μM) and cisplatin induces S-phase cell cycle arrest in HeLa cells and reduces the expression of cyclin D1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1202761-42-9
分子量 426.50
分子式 C₂₅H₃₀O₆
SMILES

COC1=C(OC/C=C(C)/C)C=CC([C@H]2[C@@]3([H])[C@](CO2)([H])[C@@H](C4=CC(OC)=C(C=C4)O)OC3)=C1
Structure Classification
- Phenols
- Monophenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (240 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 体外実験
化学情報
純度とドキュメンテーション

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Planispine A

生物活性

Cellular Effect

体外実験

化学情報

純度とドキュメンテーション

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

Planispine A

生物活性

Cellular Effect

体外実験

化学情報

純度とドキュメンテーション

Calculators

Help & FAQs

Planispine A 関連分類

HY-N20751 関連分類

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Keywords

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