Propiolamide
Based on 1 Customer Validation
Propiolamide is a monooxygenase (MMO) system activator and glutathione peroxidase 4 (GPX4) inhibitor. Propiolamide induces ROS production through interaction with the MMO system. Propiolamide promotes the accumulation of intracellular cytotoxic lipid peroxides and induces ferroptosis. Propiolamide induces programmed cell death via the apoptosis pathway. Propiolamide can be used in cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 7341-96-0
- 分子式: C3H3NO
- 分子量:69.06
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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Help & FAQs
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Apoptosis Compound Library
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Ferroptosis Compound Library
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生物活性
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GPX4 |
Propiolamide (14 mM; 0-30 min) induces microsomal monooxygenase-mediated reactive oxygen species production in CYP3A4/CPR/Cyt c and CYP3A4/NADPH systems[1].
Propiolamide (38 μM) inhibits the activity of glutathione peroxidase 4 derived from bovine red blood cells by 46%[1].
Propiolamide (30-50 μM; 12 h) induces apoptosis in HeLa cells in a concentration-dependent manner in vitro. After 12 hours of treatment, the proportion of total apoptotic cells reaches 7.13% at 30 μM and 10.33% at 50 μM[1].
Propiolamide (50 μM; 12 h) promotes lipid peroxidation in HeLa cells, which is a key marker of ferroptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa human cervical cancer cells
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Concentration:30 μM; 50 μM
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Incubation Time:12 h
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Result:Increased total apoptotic cells (early + late stage) from 4.30% (untreated control) to 7.13% at 30 μM.
Further increased total apoptotic cells to 10.33% at 50 μM.
化学情報
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CAS 番号 7341-96-0
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性状 Solid
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分子量 69.06
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分子式 C3H3NO
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Color Off-white to light yellow
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SMILES
O=C(C#C)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
純度とドキュメンテーション
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データシート (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Propiolamide 関連分類
HY-34765 関連分類
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