rel-Erteberel
rel-Erteberel is rel isomer of Erteberel (HY-18295). Erteberel is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively. Erteberel has anti-tumor activities.
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- CAS 番号: 533883-77-1
- 分子式: C18H18O3
- 分子量:282.33
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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ERβ 1.54 nM (IC50) |
ERβ 3.61 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-3 | EC50 |
3.61 nM
Compound: 7b, SERBA-2
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Activity at ERbeta in PC3 cells by transcription assay
Activity at ERbeta in PC3 cells by transcription assay
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[PMID: 17034120] |
| PC-3 | EC50 |
32.5 nM
Compound: 7b, SERBA-2
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Activity at ERalpha in PC3 cells by transcription assay
Activity at ERalpha in PC3 cells by transcription assay
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[PMID: 17034120] |
化学情報
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CAS 番号 533883-77-1
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性状 Solid
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分子量 282.33
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分子式 C18H18O3
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Color Light yellow to light brown
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SMILES
OC1=CC=C2O[C@H](C3=CC=C(C=C3)O)[C@@](CCC4)([H])[C@@]4([H])C2=C1
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別名
rel-LY500307
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (354.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Zhao L, et al. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681. [Content Brief]
[2]. Sareddy GR, et al. Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma. Sci Rep. 2016 Apr 29;6:24185. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5420 mL | 17.7098 mL | 35.4195 mL | 88.5489 mL |
| 5 mM | 0.7084 mL | 3.5420 mL | 7.0839 mL | 17.7098 mL | |
| 10 mM | 0.3542 mL | 1.7710 mL | 3.5420 mL | 8.8549 mL | |
| 15 mM | 0.2361 mL | 1.1807 mL | 2.3613 mL | 5.9033 mL | |
| 20 mM | 0.1771 mL | 0.8855 mL | 1.7710 mL | 4.4274 mL | |
| 25 mM | 0.1417 mL | 0.7084 mL | 1.4168 mL | 3.5420 mL | |
| 30 mM | 0.1181 mL | 0.5903 mL | 1.1807 mL | 2.9516 mL | |
| 40 mM | 0.0885 mL | 0.4427 mL | 0.8855 mL | 2.2137 mL | |
| 50 mM | 0.0708 mL | 0.3542 mL | 0.7084 mL | 1.7710 mL | |
| 60 mM | 0.0590 mL | 0.2952 mL | 0.5903 mL | 1.4758 mL | |
| 80 mM | 0.0443 mL | 0.2214 mL | 0.4427 mL | 1.1069 mL | |
| 100 mM | 0.0354 mL | 0.1771 mL | 0.3542 mL | 0.8855 mL |
rel-Erteberel 関連分類
HY-18295A 関連分類
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