RN983
RN983 (Compound 1) is a highly selective Bruton's tyrosine kinase (Btk) inhibitor. RN983 inhibits IgG production in B-cells with an IC50 of 2.5 nM and PGD2 production from mast cells with an IC50 of 8.3 nM. RN983 is promising for research of asthma and other allergic diseases.
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- CAS 番号: 1423129-83-2
- 分子式: C34H37FN8O3
- 分子量:624.71
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 1423129-83-2
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分子量 624.71
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分子式 C34H37FN8O3
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SMILES
O=C1C(NC2=NC=C(C3CCN(CC3)C)C=C2)=CC(C4=C(CO)C(N5N=CC6=C(C5=O)C(F)=CC(C(C)(C)C)=C6)=NC=C4)=NN1C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Phillips JE, et al. Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. J Aerosol Med Pulm Drug Deliv. 2016 Jun;29(3):233-41. [Content Brief]
[2]. Raman Mahadevan Iyer, et al. Inhibitors of bruton's tyrosine kinase. WO2014083026A1. 2014-06-05.
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RN983 関連分類
HY-117628 関連分類
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