RO 5073012
RO 5073012 is a selective, orally active and brain-penetrant TAAR1 agonist. RO 5073012 shows a Ki of 6 nM for hTAAR1 and EC50 values of 23 and 25 nM for mTAAR1 and rTAAR1. RO 5073012 can be used for the research of neurological disease, such as schizophrenia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1020814-70-3
- 分子式: C13H16ClN3
- 分子量:249.74
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
|
hTAAR1 6 nM (Ki) |
mTAAR1 23 nM (EC50) |
rTAAR1 25 nM (EC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
23 nM
Compound: 24, Ro-5073012
|
Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins
Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins
|
[PMID: 22795332] |
| HEK293 | EC50 |
23 nM
Compound: 24, Ro-5073012
|
Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins
Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins
|
[PMID: 22795332] |
| HEK293 | EC50 |
25 nM
Compound: 24, Ro-5073012
|
Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins
Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins
|
[PMID: 22795332] |
化学情報
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CAS 番号 1020814-70-3
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分子量 249.74
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分子式 C13H16ClN3
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SMILES
CC(N(C1=CC=C(Cl)C=C1)CC2=CN=CN2)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RO 5073012 関連分類
HY-117021 関連分類
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