S-23
Based on 1 publication(s) in Google Scholar
S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.63%
- CAS 番号: 1010396-29-8
- 分子式: C18H13ClF4N2O3
- 分子量:416.75
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 S-23
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生物活性
Ki: 1.7 nM (Androgen receptor)[1]
S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats (in castrated male rats)[1]
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Dosage:0.01-3 mg
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Administration:S.c.; daily for 14 d
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Result:Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.
化学情報
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CAS 番号 1010396-29-8
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性状 Solid
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分子量 416.75
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分子式 C18H13ClF4N2O3
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Color White to off-white
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SMILES
O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(Cl)C(F)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Drug Test Anal
Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes. [Abstract]2022 Feb;14(2):349-370. PMID: 34714606
溶剤 & 溶解度
DMSO : 100 mg/mL (239.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):38 [Content Brief]
[2]. Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2(11-12):589-598. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3995 mL | 11.9976 mL | 23.9952 mL | 59.9880 mL |
| 5 mM | 0.4799 mL | 2.3995 mL | 4.7990 mL | 11.9976 mL | |
| 10 mM | 0.2400 mL | 1.1998 mL | 2.3995 mL | 5.9988 mL | |
| 15 mM | 0.1600 mL | 0.7998 mL | 1.5997 mL | 3.9992 mL | |
| 20 mM | 0.1200 mL | 0.5999 mL | 1.1998 mL | 2.9994 mL | |
| 25 mM | 0.0960 mL | 0.4799 mL | 0.9598 mL | 2.3995 mL | |
| 30 mM | 0.0800 mL | 0.3999 mL | 0.7998 mL | 1.9996 mL | |
| 40 mM | 0.0600 mL | 0.2999 mL | 0.5999 mL | 1.4997 mL | |
| 50 mM | 0.0480 mL | 0.2400 mL | 0.4799 mL | 1.1998 mL | |
| 60 mM | 0.0400 mL | 0.2000 mL | 0.3999 mL | 0.9998 mL | |
| 80 mM | 0.0300 mL | 0.1500 mL | 0.2999 mL | 0.7499 mL | |
| 100 mM | 0.0240 mL | 0.1200 mL | 0.2400 mL | 0.5999 mL |
S-23 関連分類
HY-112257 関連分類
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