SDSSD
Based on 1 Customer Validation
SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.60%
- CAS 番号: 1927877-75-5
- 分子式: C17H27N5O13
- 分子量:509.42
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Peptide Library
HY-L105
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Osteogenesis Compound Library
HY-L131
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Peptide Compound Library
HY-L105S
生物活性
SDSSD colocalizes with periostin in murine MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts[2].
SDSSD reduces the subsequent binding of FITC-labeled SDSSD peptide to periostin in mouse MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts[2].
SDSSD−PU efficiently delivers FAM-labeled siRNA to murine MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts, and the uptake process depends on periostin binding[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SDSSD-modified polyurethane nanomicelles delivering GFP siRNA (10 mg/kg; tail vein injection) selectively reduce GFP mRNA and protein levels in bone tissue and isolated osteoblasts of GFP transgenic mice, demonstrating targeted gene knockdown efficacy[2].
SDSSD-modified polyurethane nanomicelles (10 mg/kg; tail vein injection) selectively deliver siRNA to bone tissues and mature osteoblasts in healthy mice, with no detectable in vivo toxicity or inflammatory response[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1927877-75-5
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性状 Solid
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分子量 509.42
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分子式 C17H27N5O13
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Color White to off-white
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配列
Ser-Asp-Ser-Ser-Asp
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シーケンスの短縮
SDSSD
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (196.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Pan Z, et al. Periostin-targeted SDSSD peptide decorated calcium phosphate nanocomposites incorporation with simvastatin for osteoporosis treatment. Nanotechnology. 2023;35(7):10.1088/1361-6528/ad0dc9. Published 2023 Dec 1. [Content Brief]
[2]. Sun Y, et al. Osteoblast-Targeting-Peptide Modified Nanoparticle for siRNA/microRNA Delivery. ACS Nano. 2016;10(6):5759-5768. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9630 mL | 9.8151 mL | 19.6302 mL | 49.0754 mL |
| 5 mM | 0.3926 mL | 1.9630 mL | 3.9260 mL | 9.8151 mL | |
| 10 mM | 0.1963 mL | 0.9815 mL | 1.9630 mL | 4.9075 mL | |
| 15 mM | 0.1309 mL | 0.6543 mL | 1.3087 mL | 3.2717 mL | |
| 20 mM | 0.0982 mL | 0.4908 mL | 0.9815 mL | 2.4538 mL | |
| 25 mM | 0.0785 mL | 0.3926 mL | 0.7852 mL | 1.9630 mL | |
| 30 mM | 0.0654 mL | 0.3272 mL | 0.6543 mL | 1.6358 mL | |
| 40 mM | 0.0491 mL | 0.2454 mL | 0.4908 mL | 1.2269 mL | |
| 50 mM | 0.0393 mL | 0.1963 mL | 0.3926 mL | 0.9815 mL | |
| 60 mM | 0.0327 mL | 0.1636 mL | 0.3272 mL | 0.8179 mL | |
| 80 mM | 0.0245 mL | 0.1227 mL | 0.2454 mL | 0.6134 mL | |
| 100 mM | 0.0196 mL | 0.0982 mL | 0.1963 mL | 0.4908 mL |
SDSSD 関連分類
HY-P11070 関連分類
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